Compound ID 391   (prev - next)

Name: Hydroxytyrosol (edit)

9 entries:
TreatmentHydroxytyrosolcognitive functionphysical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLneuronal survival / integritylocomotion in liquid mediabody wave numberheat stress resistancequantity of α-synucleinautofluorescence (age pigment / lipofuscin)mean lifespanmaximum lifespanminimum lifespanmedian lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperaturechange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)notes
30 µg/mlwhole life; start: L4OP50NGM agarFUdRN2 (wild type)22°CupnoA3; stressor: 37°C for 3h; endpoint: mean survivalBrunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. no
100 µg/mlwhole life; start: L4OP50NGM agarFUdRN2 (wild type)22°Cup11yesA3; stressor: 37°C for 3h; endpoint: mean survivalBrunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. no
250 µg/mlwhole life; start: L4OP50NGM agarFUdRN2 (wild type)22°Cup43yesA12; endpoint: activity index; no significant changes at A3 and A7 and for the thrashing rate at all agesdownyesA12; no significant changes at A3 & A7up22yesA3; stressor: 37°C for 3h; endpoint: mean survivaldown-3yesA12; no significant changes at A3 & A7; red fluorescenceup14.1yesup11.17yestime point, when 90% of the individuals are deadup12.23yestime point, when 25% of the individuals are deadup19.11yesBrunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. no
500 µg/mlwhole life; start: L4OP50NGM agarFUdRN2 (wild type)22°Cup14yesA3; stressor: 37°C for 3h; endpoint: mean survivalBrunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. no
250 µg/mlwhole life; start: L4OP50NGM agarFUdROW13 {grk-1(ok1239); pkIs2386 [unc-54p:: α-synuclein::YFP + unc-119(+)]}22°Cup34yesA7; endpoint: activity index; similar results at A3 and for the thrashing rate; similar changes in a rotenone-induced PD modeldownyesA3 & A7; similar changes in a rotenone-induced PD modeldown-14yesA12; similar results at A3 & A7Brunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. no
250 µg/mlwhole life; start: L4OP50NGM agarFUdRUA44 {baIn11 [dat-1p::α-synuclein, dat-1p::GFP]}22°CupyesA12; no significant changes at A3 & A7upyesA7; endpoint: thrashing rate; no significant changes at A3 and for the activity indexdownnoA3 & A7Brunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. no