Treatment | Hydroxytyrosol | cognitive function | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | ChEMBL | neuronal survival / integrity | locomotion in liquid media | body wave number | heat stress resistance | quantity of α-synuclein | autofluorescence (age pigment / lipofuscin) | mean lifespan | maximum lifespan | minimum lifespan | median lifespan | |||||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
30 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 22°C | up | no | A3; stressor: 37°C for 3h; endpoint: mean survival | Brunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. | no | |||||||||||||||||||||||||||||||||||||||||
100 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 22°C | up | 11 | yes | A3; stressor: 37°C for 3h; endpoint: mean survival | Brunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. | no | ||||||||||||||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 22°C | up | 43 | yes | A12; endpoint: activity index; no significant changes at A3 and A7 and for the thrashing rate at all ages | down | yes | A12; no significant changes at A3 & A7 | up | 22 | yes | A3; stressor: 37°C for 3h; endpoint: mean survival | down | -3 | yes | A12; no significant changes at A3 & A7; red fluorescence | up | 14.1 | yes | up | 11.17 | yes | time point, when 90% of the individuals are dead | up | 12.23 | yes | time point, when 25% of the individuals are dead | up | 19.11 | yes | Brunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. | no | |||||||||||||||
500 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 22°C | up | 14 | yes | A3; stressor: 37°C for 3h; endpoint: mean survival | Brunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. | no | ||||||||||||||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | OW13 {grk-1(ok1239); pkIs2386 [unc-54p:: α-synuclein::YFP + unc-119(+)]} | 22°C | up | 34 | yes | A7; endpoint: activity index; similar results at A3 and for the thrashing rate; similar changes in a rotenone-induced PD model | down | yes | A3 & A7; similar changes in a rotenone-induced PD model | down | -14 | yes | A12; similar results at A3 & A7 | Brunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. | no | |||||||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | UA44 {baIn11 [dat-1p::α-synuclein, dat-1p::GFP]} | 22°C | up | yes | A12; no significant changes at A3 & A7 | up | yes | A7; endpoint: thrashing rate; no significant changes at A3 and for the activity index | down | no | A3 & A7 | Brunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans. Int J Mol Sci 21, 2588. | no |