Treatment | Isoquercitrin | cognitive function | healthspan biomarkers | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | 5280804 | ChEMBL | CHEMBL250450 | mechanical sensory / touch response | axonal dystrophy | |||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
11 µM | whole life; start: L1 | OP50-1 | liquid S-medium | streptomycin | ID1 {igIs1 [mec-3p::htt57-128Q::CFP; lin-15(+); mec-7p::YFP]} | 20 °C | up | yes | A1 | down | yes | Farina, F., Lambert, E., Commeau, L., Lejeune, F. X., Roudier, N., Fonte, C., ... & Neri, C. (2017). The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington’s disease. Scientific reports, 7(1), 1-15. |