Compound ID 394 (prev - next)

Name: Laricitrin (5282154) (edit)

9 entries:

Treatment	Laricitrin						physical function								reproductive function								physiological function				healthspan biomarkers												lifespan								Metabolome	Target	Reference
CID (PubChem)	5282154	ChEMBL					pharyngeal pumping				body length / growth rate				number of offspring				vertex (progeny per day)				heat stress resistance				autofluorescence (age pigment / lipofuscin)				ROS level				translocation of DAF-16 to nucleus				median lifespan				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
100 µM	whole life; start: L4	OP50-1	liquid NGM	BSA, streptomycin,	N2 (wild type)	20°C	up		no	A1	none		no	A4	none		no		none		no		up	15,4	yes	A2; stressor: 37°C; endpoint: mean survival via SYTOX-staining; similar results in median survival					down	-41	yes	A2; 37°C-stress prior measurement: measurement via DCF-DA													A1	DAF-16	Büchter, C., Ackermann, D., Honnen, S., Arnold, N., Havermann, S., Koch, K., & Wätjen, W. (2015). Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food & function, 6(10), 3383-3392.
100 µM	whole life; start: L4	OP50-1	liquid NGM	BSA, streptomycin,	CF1038 [daf-16(mu86)]	20°C																	up	2,6	no	A2; stressor: 37°C; endpoint: mean survival via SYTOX-staining; unchanged median survival					up		no	A2; 37°C-stress prior measurement: measurement via DCF-DA; slightly increased only after 300 and 360 min of heat stress															Büchter, C., Ackermann, D., Honnen, S., Arnold, N., Havermann, S., Koch, K., & Wätjen, W. (2015). Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food & function, 6(10), 3383-3392.
100 µM	start: L4; stop: A3	OP50-1	liquid NGM	BSA, streptomycin,	N2 (wild type)	20°C																					down	-35,4	yes	A4																			Büchter, C., Ackermann, D., Honnen, S., Arnold, N., Havermann, S., Koch, K., & Wätjen, W. (2015). Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food & function, 6(10), 3383-3392.
100 µM	whole life; start: L4	OP50-1	liquid NGM	BSA, streptomycin,	N2 (wild type)	25°C																																	up	100	n.d.		up	54,5	yes				Büchter, C., Ackermann, D., Honnen, S., Arnold, N., Havermann, S., Koch, K., & Wätjen, W. (2015). Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food & function, 6(10), 3383-3392.
100 µM	whole life; start: L4	OP50-1	liquid NGM	BSA, streptomycin,	CF1038 [daf-16(mu86)]	25°C																																	none		n.d.		up	2,8	no				Büchter, C., Ackermann, D., Honnen, S., Arnold, N., Havermann, S., Koch, K., & Wätjen, W. (2015). Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food & function, 6(10), 3383-3392.
100 µM	1 h; start: L4/A1	OP50-1	liquid NGM	BSA, streptomycin,	TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																													up	59	yes	L4/A1											Büchter, C., Ackermann, D., Honnen, S., Arnold, N., Havermann, S., Koch, K., & Wätjen, W. (2015). Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food & function, 6(10), 3383-3392.