Compound ID 398   (prev - next)

Name: metformin (edit)

75 entries:
Treatmentmetforminphysical functionreproductive functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLpharyngeal pumpinglocomotion in liquid mediaspeed of larval developmentquantity of early reproductionquantity of late reproductiontranslocation of SKN-1 to nucleustriglyceride / fat / lipid contentautofluorescence (age pigment / lipofuscin)activity / quantity / expression of GSTsmean lifespanmedian lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperaturechange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)notes
25 mMwhole life; start: L4OP50NGM agarFUDRN2 (wild type)20°Cup18.33yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDRN2 (wild type)20°Cup33.28yesA4; up-regulation of: Methylene THF, 5-Methyl THF, S-adenosylhomocysteine; down-regulation of: S-adenosylmethionineCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
100 mMwhole life; start: L4OP50NGM agarFUDRN2 (wild type)20°Cup3.45yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
25 mMwhole life; start: A8OP50NGM agarFUDRN2 (wild type)20°Cup08.03yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: A8OP50NGM agarFUDRN2 (wild type)20°Cup1.51noCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
100 mMwhole life; start: A8OP50NGM agarFUDRN2 (wild type)20°Cdown-15.98yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: 2 generations beforeOP50NGM agarFUDRN2 (wild type)20°Cup19.33yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDRN2 (wild type)25°Cup23.20yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarN2 (wild type)25°Cup27.40yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50, UV-inactivatedNGM agarFUDRN2 (wild type)20°Cdown-15.69yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4noneaxenic medium platesFUDR, CarbenicillinN2 (wild type)20°Cdown-40.53yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
2 mMwhole life; start: L4noneaxenic medium platesFUDR, CarbenicillinN2 (wild type)20°Cdown-7.26yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
10 mMwhole life; start: L4noneaxenic medium platesFUDR, CarbenicillinN2 (wild type)20°Cdown-16.38yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDR, CarbenicillinN2 (wild type)20°Cup29.90yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4Bacillus subtilisNGM agarFUDRN2 (wild type)20°Cup9.44yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4metformin pretreated OP50NGM agarFUDR, CarbenicillinN2 (wild type)20°Cup33.30yesmetformin-free NGM platesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50-R26NGM agarFUDRN2 (wild type)20°Cup38.63yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDR, pH = 6N2 (wild type)20°Cup33.92yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDR, pH = 5.5N2 (wild type)20°Cdown-10.56noCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDR, pH = 5N2 (wild type)20°Cdown-17.42yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4BL21-Gold(DE3)NGM agarFUDRN2 (wild type)20°Cdown-29.92yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50-MR (metformin resistant)NGM agarFUDRN2 (wild type)20°Cdown-36.89yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
100 mMwhole life; start: L4OP50-MR (metformin resistant)NGM agarFUDRN2 (wild type)20°Cdown-23.19yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4HT115 (DE3)NGM agarFUDRN2 (wild type)20°Cdown-16.87yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4MG1655 bacteriaNGM agarFUDRN2 (wild type)20°Cdown-20.13yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4GD1 ubiG, GD1::pAHG (ubiG+)NGM agarFUDRN2 (wild type)20°Cup19.85yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4CS180 bacteriaNGM agarFUDRN2 (wild type)20°Cup56.65yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4CS2429 bacteriaNGM agarFUDRN2 (wild type)20°Cdown-15.55yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4HB101 bacteriaNGM agarFUDRN2 (wild type)20°Cup1.12yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50-TmpR (Trimethoprim resistant bacteria)NGM agarFUDRN2 (wild type)20°Cup32.46yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDRRB755 [metr-1(ok521)]20°Cup67.17yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDRRB2240 [sams-1(ok3033)]20°Cdown-38.24yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
2 mMwhole life; start: L4OP50NGM agarFUDRGA1001 [aak-2(ok524)]20°Cup2.21noCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
10 mMwhole life; start: L4OP50NGM agarFUDRGA1001 [aak-2(ok524)]20°Cdown-4.67yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDRGA1001 [aak-2(ok524)]20°Cdown-8.78yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDREU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]20°Cdown-15.53yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4metformin pretreated OP50NGM agarFUDR, CarbenicillinGA1001 [aak-2(ok524)]20°Cup28.66yesmetformin-free NGM platesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4metformin pretreated OP50NGM agarFUDR, CarbenicillinEU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]20°Cup20.55yesmetformin-free NGM platesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDR, 0.25% D-glucoseN2 (wild type)20°Cdown-19.68yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L4OP50NGM agarFUDR, 1% D-glucoseN2 (wild type)20°Cdown-10.85yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L1OP50NGM agarEU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]20°Cdownn.d.Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L1OP50NGM agarN2 (wild type)20°Cnonen.d.Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L1HT115 (DE3)NGM agarN2 (wild type)20°Cup30yesL4; expression of gst-4; measured via fluorescenceCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
50 mMwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup29yesL4; expression of gst-4; measured via fluorescenceCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
1 mMwhole life; start: eggs/L1OP50NGM agarN2 (wild type)20°CnonenoA1nonenononenodownnoA2; Nile Red stainingdownnoA2up13.33yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
10 mMwhole life; start: eggs/L1OP50NGM agarN2 (wild type)20°CnonenoA1nonenononenodownnoA2; Nile Red stainingdownnoA2up13.33noOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarN2 (wild type)20°CnonenoA1upyesA7 & A12; no change at A2downyesupyesdownyesA2; Nile Red stainingdownyesA2up26.67yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
100 mMwhole life; start: eggs/L1OP50NGM agarN2 (wild type)20°Cdownn.d.A2Onken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarN2 (wild type)25°Cup9.1yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
1 mMwhole life; start: eggs/L1OP50NGM agarGR1307 [daf-16(mgDf50)]20°CnonenoOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
10 mMwhole life; start: eggs/L1OP50NGM agarGR1307 [daf-16(mgDf50)]20°CnonenoOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarGR1307 [daf-16(mgDf50)]20°Cup15.38yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarTJ1052 [age-1(hx546)]20°Cup36.36yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
1 mMwhole life; start: A1OP50NGM agarCB1370 [daf-2(e1370)]20°Cup14.81noOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
10 mMwhole life; start: A1OP50NGM agarCB1370 [daf-2(e1370)]20°CnonenoOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: A1OP50NGM agarCB1370 [daf-2(e1370)]20°Cup22.22noOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
1 mMwhole life; start: eggs/L1OP50NGM agarDA1116 [eat-2(ad1116)]20°CnonenoOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
10 mMwhole life; start: eggs/L1OP50NGM agarDA1116 [eat-2(ad1116)]20°Cdown-9.52yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarDA1116 [eat-2(ad1116)]20°Cdown-9.52yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
1 mMwhole life; start: eggs/L1OP50NGM agarRB754 [aak-2(ok524)]20°CnonenoA2; Nile Red stainingdownnoA2down-5.56noOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
10 mMwhole life; start: eggs/L1OP50NGM agarRB754 [aak-2(ok524)]20°CnonenoA2; Nile Red stainingdownnoA2down-11.11yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarRB754 [aak-2(ok524)]20°CdownyesA2 & A7downnoA2; Nile Red stainingdownyesA2down-11.11yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
1 mMwhole life; start: eggs/L1OP50NGM agarMR507 [aak-2(rr48)]20°Cdown-6.25noOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
10 mMwhole life; start: eggs/L1OP50NGM agarMR507 [aak-2(rr48)]20°Cdown-6.25yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarMR507 [aak-2(rr48)]20°CdownyesA2 & A7down-18.75yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: L4OP50NGM agarKK184 [par-4(it47)]25°CnonenoOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: L4OP50NGM agarKK300 [par-4(it57)]25°Cdown-10yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarEU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]20°CnonenoOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarLD1 {ldIs7 [skn-1b/c::GFP + rol-6(su1006)]}20°CupyesL4up25yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarLG348 {skn-1(zu135)/nT1[qIs51];geIs9[gpa-4p::skn-1b::gfp; rol-6(su1006)]}20°Cdown-18.75yesOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarLG357 {skn-1(zu135)/nT1[qIs51];geIs10[ges-1p::skn-1c::gfp; rol-6(su1006)]}20°Cup15.38noOnken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no
50 mMwhole life; start: eggs/L1OP50NGM agarCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CupyesA2Onken B, Driscoll M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5, e8758. no