Treatment | p-Coumaric acid | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | 637542 | ChEMBL | CHEMBL66879 | | | | pharyngeal pumping | | | | locomotion in liquid media | | | | number of offspring | | | | speed of larval development | | | | heat stress resistance | | | | oxidative stress resistance | | | | osmotic stress resistance | | | | ROS level | | | | translocation of SKN-1 to nucleus | | | | translocation of DAF-16 to nucleus | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
50 µM | whole life; start: L1 | OP50 | liquid S-medium | | N2 (wild type) | 25°C | | | | | down | | no | | | | | | none | | no | | none | | no | A1; stressor: 37°C for 3.5 h; endpoint: survival | up | 17 | yes | A1; stressor: 5 mM paraquat; endpoint: survival | up | 28 | yes | A1; stressor: 500 mM NaCl; endpoint: survival | down | -34 | yes | A1; measured vis DCF-DA | | | | | | | | | | | | | A1; downregulation of osr-1 | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
100 µM | whole life; start: L1 | OP50 | liquid S-medium | | N2 (wild type) | 25°C | | | | | down | | no | | | | | | none | | no | | none | | no | A1; stressor: 37°C for 3.5 h; endpoint: survival | up | 17 | yes | A1; stressor: 5 mM paraquat; endpoint: survival | up | 21 | yes | A1; stressor: 500 mM NaCl; endpoint: survival | down | -25 | yes | A1; measured vis DCF-DA | | | | | | | | | | | | | A1; downregulation of osr-1 | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
50 µM | whole life; start: L1 | OP50 | NGM agar | | N2 (wild type) | 25°C | up | | no | | | | | | none | | no | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
100 µM | whole life; start: L1 | OP50 | NGM agar | | N2 (wild type) | 25°C | up | 5,5 | yes | | | | | | up | | no | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
50 µM | whole life; start: L1 | OP50 | liquid S-medium | FUdR | N2 (wild type) | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
100 µM | whole life; start: L1 | OP50 | liquid S-medium | FUdR | N2 (wild type) | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
50 µM | whole life; start: L1 | OP50 | liquid S-medium | | GR1307 [daf-16(mgDf50)] | 25°C | | | | | | | | | | | | | | | | | | | | | up | | yes | A1; stressor: 5 mM paraquat; endpoint: survival | | | | | | | | | | | | | | | | | | | | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
100 µM | whole life; start: L1 | OP50 | liquid S-medium | | GR1307 [daf-16(mgDf50)] | 25°C | | | | | | | | | | | | | | | | | | | | | up | | yes | A1; stressor: 5 mM paraquat; endpoint: survival | | | | | | | | | | | | | | | | | | | | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
50 µM | whole life; start: L1 | OP50 | liquid S-medium | | EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]] | 25°C | | | | | | | | | | | | | | | | | | | | | none | | no | A1; stressor: 5 mM paraquat; endpoint: survival | | | | | | | | | | | | | | | | | | | | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
100 µM | whole life; start: L1 | OP50 | liquid S-medium | | EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]] | 25°C | | | | | | | | | | | | | | | | | | | | | none | | no | A1; stressor: 5 mM paraquat; endpoint: survival | | | | | | | | | | | | | | | | | | | | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
50 µM | whole life; start: L1 | OP50 | liquid S-medium | | LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]} | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 20 | yes | A1 | | | | | | | | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
100 µM | whole life; start: L1 | OP50 | liquid S-medium | | LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]} | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 15 | yes | A1 | | | | | | | | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
50 µM | whole life; start: L1 | OP50 | liquid S-medium | | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | A1 | | | | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |
100 µM | whole life; start: L1 | OP50 | liquid S-medium | | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | A1 | | | | | | | | | Yue, Y., Shen, P., Xu, Y., & Park, Y. (2019). p‐Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. Journal of the Science of Food and Agriculture, 99(3), 1190-1197. | |