| Treatment | Phycoerythrin | physical function | healthspan biomarkers | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | SID: 53788505 | chEMBL | locomotion on solid media | ROS level | ||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 100 µg/ml | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | down | -75 | yes | A7; measured via DCF-DA; -77.1% during paraquat exposure | Sonani, R. R., Rastogi, R. P., Singh, N. K., Thadani, J., Patel, P. J., Kumar, J., ... & Madamwar, D. (2017). Phycoerythrin averts intracellular ROS generation and physiological functional decline in eukaryotes under oxidative stress. Protoplasma, 254(2), 849-862. | ||||||||||
| 100 µg/ml | whole life; start: L4 | OP50 | NGM agar | CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]} | 20°C | up | 20,3 | A1/A2; measurement starts 20 h after 25°C exposure; paralysis assay; similar results during paraquat exposure | Sonani, R. R., Rastogi, R. P., Singh, N. K., Thadani, J., Patel, P. J., Kumar, J., ... & Madamwar, D. (2017). Phycoerythrin averts intracellular ROS generation and physiological functional decline in eukaryotes under oxidative stress. Protoplasma, 254(2), 849-862. | |||||||||||