Treatment | Sesamin | cognitive function | physical function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | 72307 | ChEMBL | | | | | chemotaxis | | | | locomotion on solid media | | | | quantity of β-Amyloid | | | | median lifespan | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
100 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | up | 20 | yes | | up | 16,9 | yes | | | | | | Keowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664. | |
1 µg/ml | whole life; start: L1 | OP50 | NGM agar | | CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]} | 16°C | | | | | up | 2,6 | no | L4; temperature upshift to 25°C at L3; paralysis assay | | | | | | | | | | | | | | | | | Keowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664. | |
10 µg/ml | whole life; start: L1 | OP50 | NGM agar | | CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]} | 16°C | | | | | up | 5,3 | yes | L4; temperature upshift to 25°C at L3; paralysis assay | | | | | | | | | | | | | | | | | Keowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664. | |
100 µg/ml | whole life; start: L1 | OP50 | NGM agar | | CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]} | 16°C | | | | | up | 4,7 | yes | L4; temperature upshift to 25°C at L3; paralysis assay | down | | yes | Western blot; unchanged amyloid beta mRNA in qPCR | | | | | | | | | | | | | Keowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664. | |
100 µg/ml | whole life; start: L1 | OP50 | NGM agar | | CL2355 {smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]} | 16°C | up | | yes | L4/A1; temperature upshift to 25°C at L3; attractant: benzaldehyde | | | | | | | | | | | | | | | | | | | | | Keowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664. | |