Compound ID 420   (prev - next)

Name: Sesamol (68289) (edit)

8 entries:
TreatmentSesamolcognitive functionphysical functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)68289ChEMBLCHEMBL1517998chemotaxislocomotion on solid mediaquantity of β-Amyloidmedian lifespanmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
100 µg/mlwhole life; start: egg stageOP50NGM agarN2 (wild type)20°Cnonenoup9noKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.
1 µg/mlwhole life; start: L1OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°CnonenoL4; temperature upshift to 25°C at L3; paralysis assayKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.
10 µg/mlwhole life; start: L1OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°Cup0,5noL4; temperature upshift to 25°C at L3; paralysis assayKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.
100 µg/mlwhole life; start: L1OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°Cnone1,1noL4; temperature upshift to 25°C at L3; paralysis assaynonenoWestern blot; increased amyloid beta mRNA in qPCRKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.
100 µg/mlwhole life; start: L1OP50NGM agarCL2355 {smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]}16°CupyesL4/A1; temperature upshift to 25°C at L3; attractant: benzaldehydeKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.