Compound ID 421   (prev - next)

Name: Sesamolin (101746) (edit)

8 entries:
TreatmentSesamolincognitive functionphysical functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)101746ChEMBLchemotaxislocomotion on solid mediaquantity of β-Amyloidmedian lifespanmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
100 µg/mlwhole life; start: egg stageOP50NGM agarN2 (wild type)20°Cnonenoup2,9noKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.
1 µg/mlwhole life; start: L1OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°Cup0,53noL4; temperature upshift to 25°C at L3; paralysis assayKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.
10 µg/mlwhole life; start: L1OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°Cup2,1noL4; temperature upshift to 25°C at L3; paralysis assayKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.
100 µg/mlwhole life; start: L1OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°Cup5,7yesL4; temperature upshift to 25°C at L3; paralysis assaydownnoWestern blot; unchanged amyloid beta mRNA in qPCRKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.
100 µg/mlwhole life; start: L1OP50NGM agarCL2355 {smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]}16°CupyesL4/A1; temperature upshift to 25°C at L3; attractant: benzaldehydeKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.