Compound ID 422 (prev - next)

Name: spermidine (edit)

22 entries:

Treatment	spermidine						cognitive function				physical function				healthspan biomarkers								lifespan								Transcriptome	Reference	blinded
CID (PubChem)		ChEMBL					memory				locomotion on solid media				quantity of α-synuclein				autofluorescence (age pigment / lipofuscin)				mean lifespan				median lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	change compared to control	percentage change compared to control	significant (p < 0.05)	notes	change compared to control	percentage change compared to control	significant (p < 0.05)	notes	change compared to control	percentage change compared to control	significant (p < 0.05)	notes	change compared to control	percentage change compared to control	significant (p < 0.05)	notes	change compared to control	percentage change compared to control	significant (p < 0.05)	notes	change compared to control	percentage change compared to control	significant (p < 0.05)	notes
5 mM	whole life; start: eggs/L1	OP50	NGM agar		N2 (wild type)	20°C					none		no	A3, A5, A7																		Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
1 mM	whole life; start: eggs/L1	OP50	NGM agar		VC174 [wrn-1(gk99)]	20°C																	up	24.32	n.d.		up	36.36	n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
5 mM	whole life; start: eggs/L1	OP50	NGM agar		VC174 [wrn-1(gk99)]	20°C					up		yes	A3; no significant change at A5 & A7					down		yes	A7; not significant at A5	up	32.43	n.d.		up	36.36	n.d.		up-regulation of bec-1; down-regulation of sqst-1	Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
10 mM	whole life; start: eggs/L1	OP50	NGM agar		VC174 [wrn-1(gk99)]	20°C																	up	29.73	n.d.		up	36.36	n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
20 mM	whole life; start: eggs/L1	OP50	NGM agar		VC174 [wrn-1(gk99)]	20°C																	up	28.83	n.d.		up	36.36	n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
1 mM	whole life; start: eggs/L1	OP50	NGM agar		NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}	20°C																	up	16.53	n.d.		up	15.38	n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
5 mM	whole life; start: eggs/L1	OP50	NGM agar		NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}	20°C	up		yes		up		yes	A3, A5 & A7					down		yes	A7; not significant at A5	up	19.01	n.d.		up	15.38	n.d.		up-regulation of bec-1; down-regulation of sqst-1	Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
10 mM	whole life; start: eggs/L1	OP50	NGM agar		NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}	20°C																	up	19.83	n.d.		up	15.38	n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
20 mM	whole life; start: eggs/L1	OP50	NGM agar		NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}	20°C																	up	19.01	n.d.		up	15.38	n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
1 mM	whole life; start: eggs/L1	OP50	NGM agar		UM0001 {smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]; byIs161 [rab-3p::F3(delta)K280 + myo-2p::mCherry]	25°C																	up	5	n.d.		down	-22.22	n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
5 mM	whole life; start: eggs/L1	OP50	NGM agar		UM0001 {smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]; byIs161 [rab-3p::F3(delta)K280 + myo-2p::mCherry]	25°C	up		yes		up		yes	A3; no significant change at A5					down		yes	A7; not significant at A5	up	37.5	n.d.		up	22.22	n.d.		up-regulation of bec-1; down-regulation of sqst-1	Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
10 mM	whole life; start: eggs/L1	OP50	NGM agar		UM0001 {smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]; byIs161 [rab-3p::F3(delta)K280 + myo-2p::mCherry]	25°C																	up	31.25	n.d.		none		n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
20 mM	whole life; start: eggs/L1	OP50	NGM agar		UM0001 {smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]; byIs161 [rab-3p::F3(delta)K280 + myo-2p::mCherry]	25°C																	up	23.75	n.d.		none		n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
5 mM	whole life; start: eggs/L1	HT115 (DE3) with RNAi-vector against pink-1	NGM agar	IPTG	VC174 [wrn-1(gk99)]	20°C					down		no	A5; unchanged at A7					up		no	A5 & A7	none		n.d.		none		n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
5 mM	whole life; start: eggs/L1	HT115 (DE3) with RNAi-vector against pdr-1	NGM agar	IPTG	VC174 [wrn-1(gk99)]	20°C					none		no	A5 & A7					up		no	A5 & A7	none		n.d.		none		n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
5 mM	whole life; start: eggs/L1	HT115 (DE3) with RNAi-vector against pink-1	NGM agar	IPTG	NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}	20°C					none		no	A5 & A7	none		no	A5 & A7					none		n.d.		none		n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
5 mM	whole life; start: eggs/L1	HT115 (DE3) with RNAi-vector against pdr-1	NGM agar	IPTG	NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}	20°C					none		no	A5 & A7	up		no	A5 & A7					none		n.d.		none		n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
5 mM	whole life; start: eggs/L1	HT115 (DE3) with RNAi-vector against pink-1	NGM agar	IPTG	UM0001 {smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]; byIs161 [rab-3p::F3(delta)K280 + myo-2p::mCherry]	20°C					down		no	A3; unchanged at A5					up		no	A5 & A7	none		n.d.		none		n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no
5 mM	whole life; start: eggs/L1	HT115 (DE3) with RNAi-vector against pdr-1	NGM agar	IPTG	UM0001 {smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]; byIs161 [rab-3p::F3(delta)K280 + myo-2p::mCherry]	20°C					none		no	A3 & A7					none		no	A5 & A7	none		n.d.		none		n.d.			Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X (2020) Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging (Albany NY) 12, 16852-16866.	no