Treatment | Trans-2,4,5-trihydroxystilbene | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||||||||||||||||
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CID (PubChem) | ChEMBL | locomotion in liquid media | heat stress resistance | ROS level | translocation of SKN-1 to nucleus | translocation of DAF-16 to nucleus | mean lifespan | maximum lifespan | ||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
100 µM | whole life; start: A1 | OP50, heat-inactivated | liquid NGM | FUDR | N2 (wild type) | 20°C | down | -8.15 | yes | A3; stressor: 37°C; endpoint: mean lifespan | down | -39.00 | yes | A3; exposed to 37°C; measured via H2DCF-DA | daf-16, skn-1 and sir-2.1 | Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81. | ||||||||||||||||||||||||
100 µM | whole life; start: A1 | OP50, heat-inactivated | liquid NGM | FUDR | N2 (wild type) | 25°C | up | yes | A11; no significant changes at A18 | up | 6.44 | yes | up | 9.52 | n.d. | Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81. | ||||||||||||||||||||||||
100 µM | whole life; start: A1 | OP50, heat-inactivated | liquid NGM | FUDR | CF1038 [daf-16(mu86)] | 20°C | down | -24.78 | yes | A3; exposed to 37°C; measured via H2DCF-DA; significant change only during early time point | Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81. | |||||||||||||||||||||||||||||
100 µM | whole life; start: A1 | OP50, heat-inactivated | liquid NGM | FUDR | EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]] | 20°C | down | no | A3; exposed to 37°C; measured via H2DCF-DA | Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81. | ||||||||||||||||||||||||||||||
100 µM | whole life; start: A1 | OP50, heat-inactivated | liquid NGM | FUDR | VC199 [sir-2.1(ok434)] | 20°C | none | no | A3; exposed to 37°C; measured via H2DCF-DA | Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81. | ||||||||||||||||||||||||||||||
100 µM | 1 h; start: A1 | OP50, heat-inactivated | liquid NGM | FUDR | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | none | no | A1 | Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81. | ||||||||||||||||||||||||||||||
100 µM | 1 h; start: A1 | OP50, heat-inactivated | liquid NGM | FUDR | LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]} | 20°C | none | no | A1 | Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81. |