Compound ID 429   (prev - next)

Name: Trans-2,4,5-trihydroxystilbene (edit)

10 entries:
TreatmentTrans-2,4,5-trihydroxystilbenephysical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLlocomotion in liquid mediaheat stress resistanceROS leveltranslocation of SKN-1 to nucleustranslocation of DAF-16 to nucleusmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
100 µMwhole life; start: A1OP50, heat-inactivatedliquid NGMFUDRN2 (wild type)20°Cdown-8.15yesA3; stressor: 37°C; endpoint: mean lifespandown-39.00yesA3; exposed to 37°C; measured via H2DCF-DAdaf-16, skn-1 and sir-2.1Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µMwhole life; start: A1OP50, heat-inactivatedliquid NGMFUDRN2 (wild type)25°CupyesA11; no significant changes at A18up6.44yesup9.52n.d.Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µMwhole life; start: A1OP50, heat-inactivatedliquid NGMFUDRCF1038 [daf-16(mu86)]20°Cdown-24.78yesA3; exposed to 37°C; measured via H2DCF-DA; significant change only during early time pointFischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µMwhole life; start: A1OP50, heat-inactivatedliquid NGMFUDREU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°CdownnoA3; exposed to 37°C; measured via H2DCF-DAFischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µMwhole life; start: A1OP50, heat-inactivatedliquid NGMFUDRVC199 [sir-2.1(ok434)]20°CnonenoA3; exposed to 37°C; measured via H2DCF-DAFischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µM1 h; start: A1OP50, heat-inactivatedliquid NGMFUDRTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CnonenoA1Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.
100 µM1 h; start: A1OP50, heat-inactivatedliquid NGMFUDRLD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]}20°CnonenoA1Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81.