| Treatment | Trans-3,5-dimethoxy-4-hydroxystilbene | healthspan biomarkers | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | ROS level | ||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 100 µM | whole life; start: A1 | OP50, heat-inactivated | liquid NGM | FUDR | N2 (wild type) | 20°C | down | -26.00 | no | A3; exposed to 37°C; measured via H2DCF-DA | Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol 69, 73-81. | |||||