| Treatment | Trans‐communic acid | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
|---|
| CID (PubChem) | | ChEMBL | | | | | oxidative stress resistance | | | | heat stress resistance | | | | mean lifespan | | | | maximum lifespan | | | | | | | | | |
|---|
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | | | | | | |
| 1 µM | whole life; start: L4 | OP50 | liquid S-medium | | N2 (wild type) | 20°C | down | | no | A7; stressor: 0.4 M paraquat for 3h; endpoint: survival | down | | no | A5; stressor: 35°C for 16h; endpoint: survival | up | 15.8 | yes | | up | 25 | n.d. | | | | | | Kim J, Kang YG, Choi DH, Cho YU, Cho SY, Choi H, Kim HJ (2019) The natural phytochemical trans-communic acid inhibits cellular senescence and pigmentation through FoxO3a activation. Exp Dermatol 28, 1270-1278. | no |
| 10 µM | whole life; start: L4 | OP50 | liquid S-medium | | N2 (wild type) | 20°C | none | | no | A7; stressor: 0.4 M paraquat for 3h; endpoint: survival | none | | no | A5; stressor: 35°C for 16h; endpoint: survival | up | 8.9 | yes | | up | 8.3 | n.d. | | | | | | Kim J, Kang YG, Choi DH, Cho YU, Cho SY, Choi H, Kim HJ (2019) The natural phytochemical trans-communic acid inhibits cellular senescence and pigmentation through FoxO3a activation. Exp Dermatol 28, 1270-1278. | no |
| 50 µM | whole life; start: L4 | OP50 | liquid S-medium | | N2 (wild type) | 20°C | up | | no | A7; stressor: 0.4 M paraquat for 3h; endpoint: survival | up | | no | A5; stressor: 35°C for 16h; endpoint: survival | up | 7.7 | yes | | up | 8.3 | n.d. | | | | | | Kim J, Kang YG, Choi DH, Cho YU, Cho SY, Choi H, Kim HJ (2019) The natural phytochemical trans-communic acid inhibits cellular senescence and pigmentation through FoxO3a activation. Exp Dermatol 28, 1270-1278. | no |
| 1 µM | whole life; start: L4 | OP50 | liquid S-medium | | VC199 [sir-2.1(ok434)] | 20°C | | | | | | | | | up | 20.5 | yes | | up | 40 | n.d. | | | | | | Kim J, Kang YG, Choi DH, Cho YU, Cho SY, Choi H, Kim HJ (2019) The natural phytochemical trans-communic acid inhibits cellular senescence and pigmentation through FoxO3a activation. Exp Dermatol 28, 1270-1278. | no |
| 10 µM | whole life; start: L4 | OP50 | liquid S-medium | | VC199 [sir-2.1(ok434)] | 20°C | | | | | | | | | up | 21.6 | yes | | up | 40 | n.d. | | | | | | Kim J, Kang YG, Choi DH, Cho YU, Cho SY, Choi H, Kim HJ (2019) The natural phytochemical trans-communic acid inhibits cellular senescence and pigmentation through FoxO3a activation. Exp Dermatol 28, 1270-1278. | no |
| 50 µM | whole life; start: L4 | OP50 | liquid S-medium | | VC199 [sir-2.1(ok434)] | 20°C | | | | | | | | | up | 14.8 | yes | | up | 40 | n.d. | | | | | | Kim J, Kang YG, Choi DH, Cho YU, Cho SY, Choi H, Kim HJ (2019) The natural phytochemical trans-communic acid inhibits cellular senescence and pigmentation through FoxO3a activation. Exp Dermatol 28, 1270-1278. | no |
| 1 µM | whole life; start: L4 | OP50 | liquid S-medium | | DR26 [daf-16(m26)] | 20°C | | | | | | | | | up | 4.9 | no | | up | 20 | n.d. | | | | | | Kim J, Kang YG, Choi DH, Cho YU, Cho SY, Choi H, Kim HJ (2019) The natural phytochemical trans-communic acid inhibits cellular senescence and pigmentation through FoxO3a activation. Exp Dermatol 28, 1270-1278. | no |
| 10 µM | whole life; start: L4 | OP50 | liquid S-medium | | DR26 [daf-16(m26)] | 20°C | | | | | | | | | up | 1.1 | no | | up | 10 | n.d. | | | | | | Kim J, Kang YG, Choi DH, Cho YU, Cho SY, Choi H, Kim HJ (2019) The natural phytochemical trans-communic acid inhibits cellular senescence and pigmentation through FoxO3a activation. Exp Dermatol 28, 1270-1278. | no |