Compound ID 437 (prev - next)

Name: trimethoprim + metformin (edit)

7 entries:

Treatment	trimethoprim + metformin						lifespan				Reference	blinded
CID (PubChem)		ChEMBL					mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	change compared to control	percentage change compared to control	significant (p < 0.05)	notes
0.1 µg/ml TRI + 50 mM Metf	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up	43.51	yes		Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239.	no
0.2 µg/ml TRI + 50 mM Metf	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up	52.69	yes		Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239.	no
0.5 µg/ml TRI + 50 mM Metf	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up	38.69	yes		Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239.	no
1 µg/ml TRI + 50 mM Metf	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up	13.61	yes		Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239.	no