| Treatment | Zymolytic grain extract | reproductive function | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | number of offspring | speed of larval development | quantity of early reproduction | quantity of late reproduction | heat stress resistance | UV stress resistance | mean lifespan | maximum lifespan | |||||||||||||||||||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
| 0.8125 mg/ml | whole life; start: 4 generations before | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | none | no | Hou L, Jiang M, Guo Q, Shi W (2019) Zymolytic Grain Extract (ZGE) Significantly Extends the Lifespan and Enhances the Environmental Stress Resistance of Caenorhabditis elegans. Int J Mol Sci 20, 3489. | no | ||||||||||||||||||||||||||||||||||
| 1.625 mg/ml | whole life; start: 4 generations before | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | no | Hou L, Jiang M, Guo Q, Shi W (2019) Zymolytic Grain Extract (ZGE) Significantly Extends the Lifespan and Enhances the Environmental Stress Resistance of Caenorhabditis elegans. Int J Mol Sci 20, 3489. | no | ||||||||||||||||||||||||||||||||||
| 3.25 mg/ml | whole life; start: 4 generations before | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | yes | up | 7.6 | yes | up | n.d. | Hou L, Jiang M, Guo Q, Shi W (2019) Zymolytic Grain Extract (ZGE) Significantly Extends the Lifespan and Enhances the Environmental Stress Resistance of Caenorhabditis elegans. Int J Mol Sci 20, 3489. | no | |||||||||||||||||||||||||||||
| 6.5 mg/ml | whole life; start: 4 generations before | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | yes | up | 79.2 | yes | A6; stressor: UV; endpoint: mean survival | up | 13.67 | yes | similar change by using unusual high FUdR concentration | up | n.d. | similar change by using unusual high FUdR concentration | Hou L, Jiang M, Guo Q, Shi W (2019) Zymolytic Grain Extract (ZGE) Significantly Extends the Lifespan and Enhances the Environmental Stress Resistance of Caenorhabditis elegans. Int J Mol Sci 20, 3489. | no | |||||||||||||||||||||||
| 6.5 mg/ml | whole life; start: 4 generations before | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | up | n.d. | down | n.d. | up | 29.9 | yes | A2; stressor: 35°C; endpoint: mean survival | Hou L, Jiang M, Guo Q, Shi W (2019) Zymolytic Grain Extract (ZGE) Significantly Extends the Lifespan and Enhances the Environmental Stress Resistance of Caenorhabditis elegans. Int J Mol Sci 20, 3489. | no | |||||||||||||||||||||||||||