Compound ID 441 (prev - next)

Name: β-Amyrin (73145) (edit)

11 entries:

Treatment	β-Amyrin						cognitive function				physiological function				healthspan biomarkers												Transcriptome	Reference
CID (PubChem)	73145	chEMBL					neuronal survival / integrity				oxidative stress resistance				quantity of α-synuclein				ROS level				level of autophagy
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
5 µM	whole life; start: L1	OP50	liquid S-medium		N2 (wild type)	20°C					up		yes	A1; stressor: 250 µM juglone; endpoint: mean survival					down	-14	yes	A1; measurement via DCF-DA						Wei, C. C., Chang, C. H., & Liao, V. H. C. (2017). Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans. Phytomedicine, 36, 118-125.
10 µM	whole life; start: L1	OP50	liquid S-medium		N2 (wild type)	20°C					up		yes	A1; stressor: 250 µM juglone; endpoint: mean survival														Wei, C. C., Chang, C. H., & Liao, V. H. C. (2017). Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans. Phytomedicine, 36, 118-125.
15 µM	whole life; start: L1	OP50	liquid S-medium		N2 (wild type)	20°C					up		yes	A1; stressor: 250 µM juglone; endpoint: mean survival														Wei, C. C., Chang, C. H., & Liao, V. H. C. (2017). Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans. Phytomedicine, 36, 118-125.
30 µM	whole life; start: L1	OP50	liquid S-medium		N2 (wild type)	20°C					up		yes	A1; stressor: 250 µM juglone; endpoint: mean survival														Wei, C. C., Chang, C. H., & Liao, V. H. C. (2017). Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans. Phytomedicine, 36, 118-125.
5 µM	whole life; start: L1	OP50	liquid S-medium		NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}	20°C									down	-18	yes	L4									L4; upregulation of lgg-1	Wei, C. C., Chang, C. H., & Liao, V. H. C. (2017). Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans. Phytomedicine, 36, 118-125.
5 µM	whole life; start: L1	OP50	liquid S-medium		BZ555 {egIs1 [dat-1p::GFP]}	20°C	up	10	yes	A2; exposed to 6-OHDA for 1h at L3																		Wei, C. C., Chang, C. H., & Liao, V. H. C. (2017). Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans. Phytomedicine, 36, 118-125.
5 µM	whole life; start: L1	OP50	liquid S-medium		DA2123 {adls2122 [lgg-1p::GFP::lgg-1 + rol-6(su1006)]}	20°C																	up		yes	L4		Wei, C. C., Chang, C. H., & Liao, V. H. C. (2017). Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans. Phytomedicine, 36, 118-125.
0.035 μM	whole life; start: L1	OP50	liquid S-medium		N2 (wild type)	20°C					none		no	A1; stressor: 250 µM juglone for 2.5 h; endpoint: survival														Wei CC, Yen PL, Chang ST, Cheng PL, Lo YC, Liao VH (2016) Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans. PLoS One 11, e0157195.