| Treatment | 4-Caffeoylquinic acid | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 9798666 | ChEMBL | mean lifespan | |||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 50 µM | whole life; start: L4/A1 | OP50, heat-inactivated | NGM agar | FUDR | N2 (wild type) | 20°C | up | 15.23 | yes | up-regulation of sod-3, dod-3, hsp-12.6, hsp-16.1, and hsp-16.2 | DAF-16 | Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472. | ||||