Treatment | 4-Hydroxy-E-globularinin | cognitive function | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | | ChEMBL | | | | | chemotaxis | | | | pharyngeal pumping | | | | oxidative stress resistance | | | | triglyceride / fat / lipid content | | | | ROS level | | | | activity / quantity / expression of HSPs | | | | activity / quantity / expression of SODs | | | | translocation of DAF-16 to nucleus | | | | mean lifespan | | | | maximum lifespan | | | | minimum lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
200 µM | whole life; start: eggs/L1 | OP50 | NGM agar | FUdR | N2 (wild type) | 20 °C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 6,4 | yes | | up | 2 | n.d. | | up | 10,9 | n.d. | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
20 µM | whole life; start: eggs/L1 | OP50 | NGM agar | FUdR | N2 (wild type) | 20 °C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 18,8 | yes | | up | 10,9 | n.d. | | up | 50 | n.d. | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
2 µM | whole life; start: eggs/L1 | OP50 | NGM agar | FUdR | N2 (wild type) | 20 °C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 8,1 | yes | | up | 5,1 | n.d. | | up | 11,8 | n.d. | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
20 µM | whole life; start: eggs/L1 | OP50 | NGM agar | FUdR | TK22 [mev-1(kn1)] | 20 °C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -2,1 | no | | down | -5 | n.d. | | up | 9 | n.d. | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
20 µM | whole life; start: eggs/L1 | OP50 | NGM agar | FUdR | GR1307 [daf-16(mgDf50)] | 20 °C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 0,7 | no | | up | 1,5 | n.d. | | down | -7,2 | n.d. | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
20 µM | whole life; start: eggs/L1 | OP50 | NGM agar | FUdR | VC199 [sir-2.1(ok434)] | 20 °C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 20,1 | yes | | up | 8,7 | n.d. | | up | 30 | n.d. | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
200 µM | whole life; start: eggs/L1 | OP50 | NGM agar | | N2 (wild type) | 20 °C | up | | no | A5; attractant: sodium acetate | up | 5,8 | no | A5; also no significant changes in L4/A1 | up | 526,4 | yes | A2; stressor: 10 mM paraquat for 72 h; endpoint: survival | | | | | down | | yes | A2, measurement via DCF-DA | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
20 µM | whole life; start: eggs/L1 | OP50 | NGM agar | | N2 (wild type) | 20 °C | up | | yes | A5; attractant: sodium acetate | up | 20,9 | yes | A5; no significant changes in L4/A1 | up | 728 | yes | A2; stressor: 10 mM paraquat for 72 h; endpoint: survival | down | -47,5 | yes | A4; fat determination via Nile Red | down | -57 | yes | A2, measurement via DCF-DA | | | | | | | | | | | | | | | | | | | | | | | | | stage unknown; up-regulation of hsp-16.2 and sod-3 | | | DAF-16, HSP-16.2, SOD-3 | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
2 µM | whole life; start: eggs/L1 | OP50 | NGM agar | | N2 (wild type) | 20 °C | up | | yes | A5; attractant: sodium acetate | up | 10,7 | yes | A5; increased by 10% in L4/A1 | up | 685,9 | yes | A2; stressor: 10 mM paraquat for 72 h; endpoint: survival | | | | | down | | yes | A2, measurement via DCF-DA | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
20 µM | whole life; start: L4 | OP50 | NGM agar | | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20 °C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | | n.d. | A2 | | | | | | | | | | | | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
20 µM | whole life; start: L4 | OP50 | NGM agar | | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20 °C | | | | | | | | | | | | | | | | | | | | | up | 46,6 | yes | A2; prior measurement: exposure to 37°C for 2 h and recovery at 20°C for 4 h | | | | | | | | | | | | | | | | | | | | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |
20 µM | whole life; start: L4 | OP50 | NGM agar | | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20 °C | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | A2 | | | | | | | | | | | | | | | | | | | | | Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology and Medicine, 53(10), 1848-1856. | |