| Treatment | 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 6603792 | ChEMBL | oxidative stress resistance | mean lifespan | ||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 33 µM | whole life; start: A1 | Ampicillin-resistant OP50 strain | liquid S-medium | Carbenicillin, Amphotericin B, FUDR | N2 (wild type) | 20°C | up | 8.00 | no | A5; Stressor: 100 mM paraquat for 24 h; endpoint: survival | up | 11.00 | yes | Ye X, Linton JM, Schork NJ, Buck LB, Petrascheck M (2014) A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13, 206-215. | ||||||