Compound ID 59   (prev - next)

Name: Acacetin 7-O-α-l-rhamnopyranosyl (1–2) β-D-xylopyranoside (ARX) from Premna integrifolia (edit)

19 entries:
TreatmentAcacetin 7-O-α-l-rhamnopyranosyl (1–2) β-D-xylopyranoside (ARX) from Premna integrifoliaphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLpharyngeal pumpingbody length / growth ratenumber of offspringheat stress resistanceoxidative stress resistanceautofluorescence (age pigment / lipofuscin)ROS levelactivity / quantity / expression of HSPsactivity / quantity / expression of SODsactivity / quantity / expression of CTLsactivity / quantity / expression of GSTstranslocation of DAF-16 to nucleusmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
5 µMwhole life; start: L1OP50NGM agarFUDRN2 (wild type)20°Cup10.11yesAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarFUDRN2 (wild type)20°CdownyesA5 and A10downnoA4; unchanged at A8up43.83yesA2; stressor: 37°C for 4 h; endpoint: survivalup81.66yesA2; stressor: 250 µM juglone; endpoint: survivaldownyesA4; blue fluorescencedown-65.16yesA4; 37°C exposure during measurement; measured via H2DCF-DAupyesactivity / quantity / expression of SODsupyescatalase activityup39.00yesdown-regulation of sams-1; up-regulation of sir-2.1, pha-4, hsp-16.2, gst-4, and hsf-1Asthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
50 µMwhole life; start: L1OP50NGM agarFUDRN2 (wild type)20°Cup16.95yesAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: A1OP50NGM agarFUDRN2 (wild type)20°Cup17.33yesAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50, heat-inactivatedNGM agarFUDRN2 (wild type)20°Cup5.77yesAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°CdownyesAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarFUDRTK22 [mev-1(kn1)]20°Cup39.15yesAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarFUDRDA1116 [eat-2(ad1116)]20°Cup5.12noAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarFUDRGR1307 [daf-16(mgDf50)]20°Cup14.22yesAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarFUDRVC199 [sir-2.1(ok434)]20°Cup0.73noAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarFUDREU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°Cup6.38yesAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarFUDREU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]20°Cup2.00noAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarFUDRPS3551 [hsf-1(sy441)]20°Cup1.06noAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CnonenoA1; measured via fluorescenceAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CupyesA1; measured via fluorescenceAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no
25 µMwhole life; start: L1OP50NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°CupyesA1; measured via fluorescenceAsthana J, Yadav D, Pant A, Yadav AK, Gupta MM, Pandey R (2016) Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 71, 1160-1168. no