Compound ID 6   (prev - next)

Name: 7-Benzylamino-2-ethylthio-6-formyl-5-oxo-1-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (compound 4f) (edit)

7 entries:
Treatment7-Benzylamino-2-ethylthio-6-formyl-5-oxo-1-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (compound 4f)physiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLheat stress resistanceoxidative stress resistanceconcentration of N(6)-Carboxymethyllysine (CML)ROS levelmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
1 µMwhole life; start: unknownOP50NGM agarFUDRN2 (wild type)20°Cup17.54yesMekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665.
500 nMwhole life; start: unknownOP50NGM agarFUDRN2 (wild type)20°CupyesA5; stressor: 35°C for 16h; endpoint: survivalupyesA5; stressor: 40 µM paraquat; endpoint: survivaldownyesA5; measured via ELISAdownyesA2; measured via H2DCF-DAup10.30yesMekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665.
50 nMwhole life; start: unknownOP50NGM agarFUDRN2 (wild type)20°CupyesA5; stressor: 35°C for 16h; endpoint: survivalupyesA5; stressor: 40 µM paraquat; endpoint: survivaldownyesA5; measured via ELISAdownyesA2; measured via H2DCF-DAup0.64noMekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665.
5 nMwhole life; start: unknownOP50NGM agarFUDRN2 (wild type)20°CnonenoA5; stressor: 35°C for 16h; endpoint: survivalnonenoA5; stressor: 40 µM paraquat; endpoint: survivalnonenoA5; measured via ELISAnonenoA2; measured via H2DCF-DAMekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665.