| Treatment | Alanine/tyrosine mixture | physiological function | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | heat stress resistance | oxidative stress resistance | |||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 1 mM tyr + 10 mM ala | whole life; start: A1 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | yes | A3; stressor: 35°C; endpoint: mean lifespan | up | n.d. | A3; stressor: 500 µM juglone; endpoint: mean lifespan | Zhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, Guo Y, Xu L, Zhao B (2016) The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct 7, 1975-1984. | |||||||