Treatment | Alaskan chaga extract | cognitive function | physical function | reproductive function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | | ChEMBL | | | | | mechanical sensory / touch response | | | | locomotion on solid media | | | | number of offspring | | | | ROS level | | | | activity / quantity / expression of HSPs | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
50 µg/ml | whole life; start: L4 | OP50-1 | NGM agar | 50 mg/mL streptomycin | N2 (wild type) | 25°C | up | | yes | A11 (no significant change at A5, A7, and A9) | up | | yes | A11 | none | | | | | | | | | | | | up | 22.00 | yes | | | | | | Scerbak, C., Vayndorf, E. M., Hernandez, A., McGill, C., & Taylor, B. E. (2016). Mechanosensory neuron aging: differential trajectories with lifespan-extending Alaskan berry and fungal treatments in Caenorhabditis elegans. Frontiers in aging neuroscience, 8, 173. | |
200 µg/ml | whole life; start: L4 | OP50-1 | NGM agar | 50 mg/mL streptomycin | N2 (wild type) | 25°C | up | | yes | A11 (no significant change at A5, A7, and A9) | up | | yes | A11 | none | | | | down | -46.5 | no | | down | | no | | up | 21.00 | yes | | | | | | Scerbak, C., Vayndorf, E. M., Hernandez, A., McGill, C., & Taylor, B. E. (2016). Mechanosensory neuron aging: differential trajectories with lifespan-extending Alaskan berry and fungal treatments in Caenorhabditis elegans. Frontiers in aging neuroscience, 8, 173. | |
800 µg/ml | whole life; start: L4 | OP50-1 | NGM agar | 50 mg/mL streptomycin | N2 (wild type) | 25°C | none | | | | up | | yes | A11 | | | | | | | | | | | | | up | 21.00 | yes | | | | | | Scerbak, C., Vayndorf, E. M., Hernandez, A., McGill, C., & Taylor, B. E. (2016). Mechanosensory neuron aging: differential trajectories with lifespan-extending Alaskan berry and fungal treatments in Caenorhabditis elegans. Frontiers in aging neuroscience, 8, 173. | |
50 µg/ml | whole life; start: L4 | OP50, UV-inactivated | NGM agar | 50 mg/mL streptomycin | N2 (wild type) | 25°C | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | | Scerbak, C., Vayndorf, E. M., Hernandez, A., McGill, C., & Taylor, B. E. (2016). Mechanosensory neuron aging: differential trajectories with lifespan-extending Alaskan berry and fungal treatments in Caenorhabditis elegans. Frontiers in aging neuroscience, 8, 173. | |
200 µg/ml | whole life; start: L4 | OP50, UV-inactivated | NGM agar | 50 mg/mL streptomycin | N2 (wild type) | 25°C | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | | Scerbak, C., Vayndorf, E. M., Hernandez, A., McGill, C., & Taylor, B. E. (2016). Mechanosensory neuron aging: differential trajectories with lifespan-extending Alaskan berry and fungal treatments in Caenorhabditis elegans. Frontiers in aging neuroscience, 8, 173. | |
800 µg/ml | whole life; start: L4 | OP50, UV-inactivated | NGM agar | 50 mg/mL streptomycin | N2 (wild type) | 25°C | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | | Scerbak, C., Vayndorf, E. M., Hernandez, A., McGill, C., & Taylor, B. E. (2016). Mechanosensory neuron aging: differential trajectories with lifespan-extending Alaskan berry and fungal treatments in Caenorhabditis elegans. Frontiers in aging neuroscience, 8, 173. | |