Compound ID 69 (prev - next)

Name: Allantoin (204) (edit)

8 entries:

Treatment	Allantoin						physical function								lifespan				Transcriptome	Reference
CID (PubChem)	204	ChEMBL					pharyngeal pumping				locomotion on solid media				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
250 µM	whole life; start: L4	OP50, ethanol- and UV-inactivated	NGM agar	FUDR	N2 (wild type)	20°C	up	230.04	yes	A10; non-significantly increased at A5; unchanged at A1 and A15	up		no	A1, A5, A10, and A15	up	20.10	yes		whole genome array; supplemental table available	Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
250 µM	whole life; start: L4	OP50, ethanol- and UV-inactivated	NGM agar	FUDR	DA465[eat-2(ad465)]	20°C									up	4.20	variable		whole genome array; supplemental table available	Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
500 µM	whole life; start: L4	OP50, ethanol- and UV-inactivated	NGM agar	FUDR	N2 (wild type)	20°C									up	14.30	yes			Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
500 µM	whole life; start: L4	OP50, ethanol- and UV-inactivated	NGM agar	FUDR	DA465[eat-2(ad465)]	20°C									up	3.30	yes			Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
250 µM	whole life; start: L4	OP50, ethanol- and UV-inactivated	NGM agar	FUDR	GR1307 [daf-16(mgDf50)]	20°C									up	19.70	yes			Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.