Compound ID 73   (prev - next)

Name: Alpinia zerumbet Leaf (Phenol-rich fraction) (edit)

11 entries:
TreatmentAlpinia zerumbet Leaf (Phenol-rich fraction)physiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLheat stress resistanceoxidative stress resistanceactivity / quantity / expression of HSPsactivity / quantity / expression of SODsmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
2.5 µg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup8.3yesA5; Stressor: 35°C; endpoint: mean lifespan; median lifespan is also significantly increasedup80.6yesA2; Stressor: 0.5 mM H2O2 for 8 hUpadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S (2013) Significant longevity-extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem 77, 217-223.
5.0 µg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup13.45yesA5; Stressor: 35°C; endpoint: mean lifespan; median lifespan is also significantly increasedup93.7yesA2; Stressor: 0.5 mM H2O2 for 8 hUpadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S (2013) Significant longevity-extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem 77, 217-223.
10.0 µg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup16.2yesA5; Stressor: 35°C; endpoint: mean lifespan; median lifespan is also significantly increasedup112.8yesA2; Stressor: 0.5 mM H2O2 for 8 hSOD-3 and HSP-16.2Upadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S (2013) Significant longevity-extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem 77, 217-223.
25 µg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup4.22yesUpadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S (2013) Significant longevity-extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem 77, 217-223.
50 µg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup20.77yesUpadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S (2013) Significant longevity-extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem 77, 217-223.
100 µg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup45.49yesUpadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S (2013) Significant longevity-extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem 77, 217-223.
10.0 µg/mlwhole life; start: L1OP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°Cup143.00n.d.A1; measured via fluorescence; up-regulation also visible via RT-PCRUpadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S (2013) Significant longevity-extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem 77, 217-223.
10.0 µg/mlwhole life; start: L1OP50NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°Cup150.00yesA1; 12 h before measurement: heat shock at 35°C for 2 h; measured via fluorescence; up-regulation also visible via RT-PCRUpadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S (2013) Significant longevity-extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem 77, 217-223.