Treatment | Anacardium occidentale, hexane extract | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | | ChEMBL | | | | | pharyngeal pumping | | | | body length / growth rate | | | | number of offspring | | | | oxidative stress resistance | | | | ROS level | | | | activity / quantity / expression of HSPs | | | | translocation of DAF-16 to nucleus | | | | activity / quantity / expression of SODs | | | | translocation of SKN-1 to nucleus | | | | autofluorescence (age pigment / lipofuscin) | | | | activity / quantity / expression of GSTs | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | | | | | | |
25 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | N2 (wild type) | 20°C | | | | | | | | | | | | | up | 36.71 | yes | A2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival rate | down | -45.24 | yes | A1; measured via H2DCF-DA | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
50 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | N2 (wild type) | 20°C | | | | | | | | | | | | | up | 49.15 | yes | A2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival rate | up | | no | A1; measured via H2DCF-DA | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
100 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | N2 (wild type) | 20°C | | | | | | | | | | | | | up | | no | A2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival rate | up | | no | A1; measured via H2DCF-DA | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
25 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | CF1038 [daf-16(mu86)] | 20°C | | | | | | | | | | | | | up | | no | A2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival rate | none | | no | A1; measured via H2DCF-DA | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
50 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | CF1038 [daf-16(mu86)] | 20°C | | | | | | | | | | | | | up | | no | A2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival rate | down | | no | A1; measured via H2DCF-DA | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
100 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | CF1038 [daf-16(mu86)] | 20°C | | | | | | | | | | | | | up | | no | A2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival rate | down | | no | A1; measured via H2DCF-DA | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
25 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | TJ375 {gpIs1 [hsp-16.2p::GFP]} | 20°C | | | | | | | | | | | | | | | | | | | | | down | -64.9 | yes | A2; pre-exposed to juglone | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
50 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | TJ375 {gpIs1 [hsp-16.2p::GFP]} | 20°C | | | | | | | | | | | | | | | | | | | | | down | -67.77 | yes | A2; pre-exposed to juglone | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
100 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | TJ375 {gpIs1 [hsp-16.2p::GFP]} | 20°C | | | | | | | | | | | | | | | | | | | | | down | -45.86 | yes | A2; pre-exposed to juglone | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
25 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 25.41 | yes | A2 | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
50 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 23.7 | yes | A2 | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
100 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 22.64 | yes | A2 | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
25 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | up | 59.73 | yes | A2 | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
50 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | up | 63.74 | yes | A2 | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
100 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | up | 57.45 | yes | A2 | | | | | | | | | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
25 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 41.99 | yes | A2; pre-exposed to juglone | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
50 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 17.68 | yes | A2; pre-exposed to juglone | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
100 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | A2; pre-exposed to juglone | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
25 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | A2 | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
50 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | A2 | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
100 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | A2 | | | | | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
25 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | BA17 [fem-1(hc17)] | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -11.96 | yes | A16; blue fluorescence | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
50 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | BA17 [fem-1(hc17)] | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -17.55 | yes | A16; blue fluorescence | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
100 µg/ml | whole life; start: L1 | OP50 | liquid S-medium | | BA17 [fem-1(hc17)] | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -12.62 | yes | A16; blue fluorescence | | | | | | | | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
25 µg/ml | whole life; start: L4 | OP50 | NGM agar | | N2 (wild type) | 20°C | up | | yes | A5, A8, A10, A12 | none | | no | A1 | none | | no | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 4.41 | no | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
50 µg/ml | whole life; start: L4 | OP50 | NGM agar | | N2 (wild type) | 20°C | up | | yes | A5, A8, A10; no significant change at A12 | none | | no | A1 | none | | no | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 20.31 | yes | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
100 µg/ml | whole life; start: L4 | OP50 | NGM agar | | N2 (wild type) | 20°C | up | | yes | A5, A8, A10; no significant change at A12 | none | | no | A1 | none | | no | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 5.32 | no | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
25 µg/ml | whole life; start: L4 | OP50 | NGM agar | | TK22 [mev-1(kn1)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -0.91 | no | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
50 µg/ml | whole life; start: L4 | OP50 | NGM agar | | TK22 [mev-1(kn1)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 3.16 | no | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |
100 µg/ml | whole life; start: L4 | OP50 | NGM agar | | TK22 [mev-1(kn1)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 11.31 | no | | | | | | Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. | no |