Treatment | Whole apple extract | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||||
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CID (PubChem) | 135316389 | ChEMBL | locomotion on solid media | number of offspring | heat stress resistance | oxidative stress resistance | pathogen stress resistance | UV stress resistance | autofluorescence (age pigment / lipofuscin) | mean lifespan | maximum lifespan | |||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
2.5 mg/ml | whole life; start: A1 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | yes | A12, A14, and A16 | none | no | up | 29.81 | yes | A3; Stressor: 35°C for 10.5 h | up | 55.1 | yes | A3; Stressor: 10 mM paraquat; endpoint: mean lifespan | up | 22.0 | yes | A3; Stressor: Pseudomonas aeruginosa; endpoint: mean lifespan | up | 22.6 | yes | A3; Stressor: 1200 J/m2; endpoint: mean lifespan | down | yes | A8; green fluorescence | up | 18.7 | yes | none | Vayndorf EM, Lee SS, Liu RH (2013) Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans. J Funct Foods 5, 1236-1243. | no | ||||||||||||
5 mg/ml | whole life; start: A1 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | yes | A12, A14, and A16 | none | no | up | 58.36 | yes | A3; Stressor: 35°C for 10.5 h | up | 89.3 | yes | A3; Stressor: 10 mM paraquat; endpoint: mean lifespan | up | 35.2 | yes | A3; Stressor: Pseudomonas aeruginosa; endpoint: mean lifespan | up | 46.2 | yes | A3; Stressor: 1200 J/m2; endpoint: mean lifespan | down | yes | A8; green fluorescence | up | 24.1 | yes | up | 25.00 | Vayndorf EM, Lee SS, Liu RH (2013) Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans. J Funct Foods 5, 1236-1243. | no | |||||||||||
10 mg/ml | whole life; start: A1 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | yes | A12, A14, and A16 | none | no | up | 63.15 | yes | A3; Stressor: 35°C for 10.5 h | up | 71.8 | yes | A3; Stressor: 10 mM paraquat; endpoint: mean lifespan | up | 24.5 | yes | A3; Stressor: Pseudomonas aeruginosa; endpoint: mean lifespan | up | 61.5 | yes | A3; Stressor: 1200 J/m2; endpoint: mean lifespan | up | 39.6 | yes | up | 25.00 | Vayndorf EM, Lee SS, Liu RH (2013) Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans. J Funct Foods 5, 1236-1243. | no |