Compound ID 78   (prev - next)

Name: Whole apple extract (135316389) (edit)

6 entries:
TreatmentWhole apple extractphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)135316389ChEMBLlocomotion on solid medianumber of offspringheat stress resistanceoxidative stress resistancepathogen stress resistanceUV stress resistanceautofluorescence (age pigment / lipofuscin)mean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
2.5 mg/mlwhole life; start: A1OP50NGM agarFUDRN2 (wild type)20°CupyesA12, A14, and A16nonenoup29.81yesA3; Stressor: 35°C for 10.5 hup55.1yesA3; Stressor: 10 mM paraquat; endpoint: mean lifespanup22.0yesA3; Stressor: Pseudomonas aeruginosa; endpoint: mean lifespanup22.6yesA3; Stressor: 1200 J/m2; endpoint: mean lifespandownyesA8; green fluorescenceup18.7yesnoneVayndorf EM, Lee SS, Liu RH (2013) Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans. J Funct Foods 5, 1236-1243.no
5 mg/mlwhole life; start: A1OP50NGM agarFUDRN2 (wild type)20°CupyesA12, A14, and A16nonenoup58.36yesA3; Stressor: 35°C for 10.5 hup89.3yesA3; Stressor: 10 mM paraquat; endpoint: mean lifespanup35.2yesA3; Stressor: Pseudomonas aeruginosa; endpoint: mean lifespanup46.2yesA3; Stressor: 1200 J/m2; endpoint: mean lifespandownyesA8; green fluorescenceup24.1yesup25.00Vayndorf EM, Lee SS, Liu RH (2013) Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans. J Funct Foods 5, 1236-1243.no
10 mg/mlwhole life; start: A1OP50NGM agarFUDRN2 (wild type)20°CupyesA12, A14, and A16nonenoup63.15yesA3; Stressor: 35°C for 10.5 hup71.8yesA3; Stressor: 10 mM paraquat; endpoint: mean lifespanup24.5yesA3; Stressor: Pseudomonas aeruginosa; endpoint: mean lifespanup61.5yesA3; Stressor: 1200 J/m2; endpoint: mean lifespanup39.6yesup25.00Vayndorf EM, Lee SS, Liu RH (2013) Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans. J Funct Foods 5, 1236-1243.no