Treatment | Green tea (Camellia sinensis), aqueous extract | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||||||||
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CID (PubChem) | ChEMBL | pharyngeal pumping | oxidative stress resistance | UV stress resistance | activity / quantity / expression of HSPs | maximum lifespan | ||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
100 µg/ml | start: L2; stop: A1 | OP50 | liquid S-medium | N2 (wild type) | 20°C | up | 148.97 | yes | Stressor: 80 µM juglone for 24 h; endpoint: survival | HSP-16.2 | Abbas S, Wink M (2014) Green Tea Extract Induces the Resistance of Caenorhabditis elegans against Oxidative Stress. Antioxidants (Basel). 3, 129-143. | |||||||||||||||||||||
100 µg/ml | start: L2; stop: A1 | OP50 | liquid S-medium | TJ375 {gpIs1 [hsp-16.2p::GFP]} | 20°C | down | -68.43 | yes | A2; pre-exposed to 20 µM juglone for 24 h | Abbas S, Wink M (2014) Green Tea Extract Induces the Resistance of Caenorhabditis elegans against Oxidative Stress. Antioxidants (Basel). 3, 129-143. | ||||||||||||||||||||||
0.005 % | whole life; start: A1 | OP50 | M9 buffer | N2 (wild type) | 20°C | none | n.d. | Prasanth MI, Gayathri S, Bhaskar JP, Krishnan V, Balamurugan K (2020) Analyzing the Synergistic Effects of Antioxidants in Combating Photoaging Using Model Nematode, Caenorhabditis elegans. Photochem Photobiol 96, 139-147. | no | |||||||||||||||||||||||
0.01 % | whole life; start: A1 | OP50 | M9 buffer | N2 (wild type) | 20°C | up | yes | stressor: UV-A for 3h | up | n.d. | Prasanth MI, Gayathri S, Bhaskar JP, Krishnan V, Balamurugan K (2020) Analyzing the Synergistic Effects of Antioxidants in Combating Photoaging Using Model Nematode, Caenorhabditis elegans. Photochem Photobiol 96, 139-147. | no | ||||||||||||||||||||
0.1 % | whole life; start: A1 | OP50 | M9 buffer | N2 (wild type) | 20°C | up | n.d. | Prasanth MI, Gayathri S, Bhaskar JP, Krishnan V, Balamurugan K (2020) Analyzing the Synergistic Effects of Antioxidants in Combating Photoaging Using Model Nematode, Caenorhabditis elegans. Photochem Photobiol 96, 139-147. | no | |||||||||||||||||||||||
1 % | whole life; start: A1 | OP50 | M9 buffer | N2 (wild type) | 20°C | up | n.d. | Prasanth MI, Gayathri S, Bhaskar JP, Krishnan V, Balamurugan K (2020) Analyzing the Synergistic Effects of Antioxidants in Combating Photoaging Using Model Nematode, Caenorhabditis elegans. Photochem Photobiol 96, 139-147. | no | |||||||||||||||||||||||
0.01 % | whole life; start: A1 | OP50 | NGM agar | N2 (wild type) | 20°C | up | yes | daily measurement | Prasanth MI, Gayathri S, Bhaskar JP, Krishnan V, Balamurugan K (2020) Analyzing the Synergistic Effects of Antioxidants in Combating Photoaging Using Model Nematode, Caenorhabditis elegans. Photochem Photobiol 96, 139-147. | no |