Compound ID 8 (prev - next)

Name: 10-O-trans-p-Coumaroylcatalpol (edit)

12 entries:

Treatment	10-O-trans-p-Coumaroylcatalpol						cognitive function				physical function				physiological function				healthspan biomarkers												lifespan												Target	Reference
CID (PubChem)		ChEMBL					chemotaxis				pharyngeal pumping				oxidative stress resistance				quantity of α-synuclein				ROS level				translocation of DAF-16 to nucleus				mean lifespan				maximum lifespan				minimum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
2 µM	whole life; start: egg stage	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A6; attractant: 1Msodium acetate	up		yes	A1; unchanged in A6	up		yes	A2; stressor: 10 mM paraquat for 72 h; endpoint: survival					down		yes	A3; measured via H2DCF-DA					up	8.25	yes		up	12	n.d.		up	13.04	n.d.			Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, Nazir A, Pandey R (2012) Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces α synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets 11, 984-992.
20 µM	whole life; start: egg stage	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A6; attractant: 1Msodium acetate	up		yes	A1 and A6	up		yes	A2; stressor: 10 mM paraquat for 72 h; endpoint: survival					down	-40.10	yes	A3; measured via H2DCF-DA					up	17.96	yes		up	13.32	n.d.		up	47.83	n.d.		daf-16	Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, Nazir A, Pandey R (2012) Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces α synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets 11, 984-992.
200 µM	whole life; start: egg stage	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A6; attractant: 1Msodium acetate	up		yes	A1 and A6	up		yes	A2; stressor: 10 mM paraquat for 72 h; endpoint: survival					down		yes	A3; measured via H2DCF-DA					up	5.14	no		down	-1.36	n.d.		up	30.43	n.d.			Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, Nazir A, Pandey R (2012) Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces α synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets 11, 984-992.
20 µM	whole life; start: egg stage	OP50	NGM agar	FUDR	TK22 [mev-1(kn1)]	20°C																									up	1.70	no		down	-8.41	n.d.		up	6.49	n.d.			Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, Nazir A, Pandey R (2012) Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces α synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets 11, 984-992.
20 µM	whole life; start: egg stage	OP50	NGM agar	FUDR	GR1307 [daf-16(mgDf50)]	20°C																									down	-2.40	no		down	-4.48	n.d.		down	-8.11	n.d.			Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, Nazir A, Pandey R (2012) Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces α synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets 11, 984-992.
20 µM	whole life; start: egg stage	OP50	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	20°C																									up	15.06	yes		up	10.41	n.d.		up	14.29	n.d.			Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, Nazir A, Pandey R (2012) Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces α synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets 11, 984-992.
20 µM	whole life; start: L4	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																					up		n.d.	A2														Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, Nazir A, Pandey R (2012) Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces α synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets 11, 984-992.
200 µM	whole life; start: L4	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																					up		n.d.	A2														Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, Nazir A, Pandey R (2012) Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces α synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets 11, 984-992.
20 µM	whole life; start: egg stage	OP50	NGM agar		NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}	22°C													down	-24.32	yes	A1; measured via fluorescence																						Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, Nazir A, Pandey R (2012) Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces α synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets 11, 984-992.