Compound ID 82   (prev - next)

Name: Arsenite (443495) (edit)

15 entries:
TreatmentArsenitephysical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)443495ChEMBLlocomotion in liquid mediaheat stress resistanceoxidative stress resistanceROS leveloxygen consumption rate (OCR)activity / quantity / expression of SODsactivity / quantity / expression of CTLsGSH levelmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
0.01 µMwhole life; start: L4OP50, heat-inactivatedNGM agarampicillinN2 (wild type)20°Cdown-2.49noup0.29n.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
0.1 µMwhole life; start: L4OP50, heat-inactivatedNGM agarampicillinN2 (wild type)20°Cupyesadult animals; endpoint: distance movedupyesadult animals; Stressor: 37°C; endpoint: mean lifespanupyesA6; Stressor: 10 mM paraquat; endpoint: mean lifespanvariableyesincreased ROS-level in A1 and A2; decreased ROS-level in A5; endpoints: mitochondrial ROS formation and hydrogen peroxide formationupyesA5; unchanged in A1 and A2nonenoA1, A2, and A5; SOD-activity measured via oxidation of WST-1upyesA2, and A5; unchanged at A1; catalase-activity measured by formaldehyde formationvariableyesdecreased ratio in A1; increased ratio in A2 (not significant) and A5;up9.54yesup11.50n.d.RNA deep sequencing in A2; list of differentially expressed genes in the supplementDAF-16, SKN-1, TIN-9.1, and MTL-2Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
1 µMwhole life; start: L4OP50, heat-inactivatedNGM agarampicillinN2 (wild type)20°Cdown-3.32nodown-5.6n.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
10 µMwhole life; start: L4OP50, heat-inactivatedNGM agarampicillinN2 (wild type)20°Cdown-9.13yesdown-17.40n.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
100 µMwhole life; start: L4OP50, heat-inactivatedNGM agarampicillinN2 (wild type)20°Cdown-30.29yesdown-32.15n.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
1000 µMwhole life; start: L4OP50, heat-inactivatedNGM agarampicillinN2 (wild type)20°Cdown-48.55yesdown-49.85n.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
0.1 µMwhole life; start: L4OP50, heat-inactivatedNGM agar10 µM butylated hydroxyanisole; ampicillinN2 (wild type)20°CnonenoA1 and A5; endpoints: mitochondrial ROS formation and hydrogen peroxide formationnonenoA5; catalase-activity measured by formaldehyde formationdown-2.44nononen.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
0.1 µMwhole life; start: L4OP50, heat-inactivatedNGM agar1 mM N-acetyl-L-cysteine; ampicillinN2 (wild type)20°Cup1.67nononen.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
0.1 µMwhole life; start: L4OP50, heat-inactivatedNGM agarampicillinEU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°Cdown-4.49yesdown-12.27n.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
0.1 µMwhole life; start: L4OP50, heat-inactivatedNGM agarampicillinunknown strain [daf-16(mgDf47)]20°Cdown-3.49yesdown-3.94n.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
0.1 µMwhole life; start: L4OP50, heat-inactivatedNGM agarampicillinVC2268 [tin-9.1(ok2194)]20°Cnonenoup1.42n.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.
0.1 µMwhole life; start: L4OP50, heat-inactivatedNGM agarampicillinVC128 [mtl-2(gk125)]20°Cup1.66noup8.62n.d.Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M (2013) Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517.