Compound ID 84 (prev - next)

Name: Ascarosides ascr#3 (edit)

38 entries:

Treatment	Ascarosides ascr#3						reproductive function				physiological function				lifespan				Target	Reference
CID (PubChem)							number of offspring				heat stress resistance				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
0.04 nM	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C									up	10,6	yes		DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
4 nM	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20 °C									up	12,9	yes		DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C	up		n.d.						up	21,2	yes		DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
1 µM	whole life; start. L4	OP50	NGM agar		N2 (wild type)	20°C									up	12,8	yes		DAF-37; SIR-2.1	Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
0.04 nM	whole life; start. L4	OP50	NGM agar		VC199 [sir-2.1(ok434)]	20°C									down	-3,2	no			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
4 nM	whole life; start. L4	OP50	NGM agar		VC199 [sir-2.1(ok434)]	20 °C									up	3,2	no			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50	NGM agar		VC199 [sir-2.1(ok434)]	20°C									down	-4,8	no			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
0.04 nM	whole life; start. L4	OP50	NGM agar		unknown strain {daf-16(mgDf50); unc-119(ed3); pkIs1642[unc-119(+) + R11A8.5(+) + sir-2.1(+)]}	20°C									up	14,4	yes			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
4 nM	whole life; start. L4	OP50	NGM agar		unknown strain {daf-16(mgDf50); unc-119(ed3); pkIs1642[unc-119(+) + R11A8.5(+) + sir-2.1(+)]}	20°C									up	16,4	yes			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50	NGM agar		unknown strain {daf-16(mgDf50); unc-119(ed3); pkIs1642[unc-119(+) + R11A8.5(+) + sir-2.1(+)]}	20°C									up	14,4	yes			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
0.04 nM	whole life; start. L4	OP50	NGM agar		CF1038 [daf-16(mu86)]	20°C									down	-2,7	no			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
4 nM	whole life; start. L4	OP50	NGM agar		CF1038 [daf-16(mu86)]	20°C									up	8,8	yes			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
40 nM	whole life; start. L4	OP50	NGM agar		CF1038 [daf-16(mu86)]	20°C									up	8,8	yes			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50	NGM agar		CF1038 [daf-16(mu86)]	20°C									up	5,1	yes			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50	NGM agar		AA86 [daf-12(rh61rh411)]	20°C									up	14,3	yes	mean from 2 individual trials		Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50	NGM agar		DR1572 [daf-2(e1368)]	20°C									up	7,5	yes			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50	NGM agar		unknown strain; genotype: [daf-7(e1372); daf-3(e1376)]	20°C									up	19	yes	mean from 2 individual trials		Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
1 µM	whole life; start. L4	OP50	NGM agar without peptone		N2 (wild type)	20°C									up		no			Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
20 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		VC199 [sir-2.1(ok434)]	20°C					none		no	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
200 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		VC199 [sir-2.1(ok434)]	20°C					up		no	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
1 µM	whole life; start. L4	OP50, UV-inactivated	NGM agar		VC199 [sir-2.1(ok434)]	20°C					up		no	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
2 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		N2 (wild type)	20°C					none		no	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
200 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		N2 (wild type)	20°C					up	29,9	yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
1 µM	whole life; start. L4	OP50, UV-inactivated	NGM agar		N2 (wild type)	20°C					up	29,9	yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
200 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		DR62 [daf-7(m62)]	20°C					up		yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
200 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		CB1372 [daf-7(e1372)]	20°C					up		yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
200 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		CB1376 [daf-3(e1376)]	20°C					up		yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		CB1376 [daf-3(e1376)]	20°C					up		yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
200 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		DR1572 [daf-2(e1368)]	20°C					up		yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		DR1572 [daf-2(e1368)]	20°C					up		no	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
0.04 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		CF1038 [daf-16(mu86)]	20°C					down		no	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
4 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		CF1038 [daf-16(mu86)]	20°C					up		yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
200 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		CF1038 [daf-16(mu86)]	20°C					up		yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		CF1038 [daf-16(mu86)]	20°C					up		yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.
400 nM	whole life; start. L4	OP50, UV-inactivated	NGM agar		AA86 [daf-12(rh61rh411)]	20°C					up		yes	A1; stressor: 35°C; endpoint: survival						Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., ... & Schroeder, F. C. (2013). Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proceedings of the National Academy of Sciences, 110(14), 5522-5527.