Treatment | Aspalathin | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | 16752601 | ChEMBL | | | | | oxidative stress resistance | | | | ROS level | | | | activity / quantity / expression of HSPs | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
10 µM | whole life; start: L1 | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | down | | no | A1; measurement via H2DCF-DA | | | | | none | | no | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
20 µM | whole life; start: L1 | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | down | -34.80 | yes | A1; measurement via H2DCF-DA | | | | | none | | no | | increased expression of daf-16 (1.2 fold ,p < 0.05) and sod-3 (4.2 fold, p < 0.001) | | | DAF-16 | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
50 µM | whole life; start: L1 | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | down | -47.40 | yes | A1; measurement via H2DCF-DA | | | | | none | | no | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
10 µM | whole life; start: L1 | OP50 | NGM agar | | TK22 [mev-1(kn1)] | 20°C | | | | | down | | no | A1; measurement via H2DCF-DA | | | | | | | | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
20 µM | whole life; start: L1 | OP50 | NGM agar | | TK22 [mev-1(kn1)] | 20°C | | | | | down | -43.10 | yes | A1; measurement via H2DCF-DA | | | | | | | | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
50 µM | whole life; start: L1 | OP50 | NGM agar | | TK22 [mev-1(kn1)] | 20°C | | | | | down | -42.30 | yes | A1; measurement via H2DCF-DA | | | | | | | | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
10 µM | whole life; start: L1 | OP50 | NGM agar | 50 mM glucose | N2 (wild type) | 20°C | | | | | | | | | | | | | up | | no | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
20 µM | whole life; start: L1 | OP50 | NGM agar | 50 mM glucose | N2 (wild type) | 20°C | | | | | | | | | | | | | up | 24.40 | yes | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
50 µM | whole life; start: L1 | OP50 | NGM agar | 50 mM glucose | N2 (wild type) | 20°C | | | | | | | | | | | | | up | 20.50 | yes | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
10 µM | whole life; start: L1 | OP50 | liquid S-medium | | N2 (wild type) | 20°C | up | 158.20 | yes | A1; Stressor: 400 µM juglone for 6 h | | | | | | | | | | | | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
20 µM | whole life; start: L1 | OP50 | liquid S-medium | | N2 (wild type) | 20°C | up | 160.10 | yes | A1; Stressor: 400 µM juglone for 6 h | | | | | | | | | | | | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
50 µM | whole life; start: L1 | OP50 | liquid S-medium | | N2 (wild type) | 20°C | up | 152.60 | yes | A1; Stressor: 400 µM juglone for 6 h | | | | | | | | | | | | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |
20 µM | start: L1; stop: L4 (48h) | OP50 | liquid S-medium | | TJ375 {gpIs1 [hsp-16.2p::GFP]} | 20°C | | | | | | | | | down | -27.00 | yes | A1; exposure to 20 µM juglone for 24 h before measurement; measurement via fluorescence | | | | | | | | | Chen W, Sudji IR, Wang E, Joubert E, van Wyk BE, Wink M (2013) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine 20, 380-386. | |