Compound ID 86 (prev - next)

Name: Aspirin (2244) (edit)

24 entries:

Treatment	Aspirin						physical function								reproductive function								physiological function				healthspan biomarkers																lifespan				Transcriptome	Target	Reference
CID (PubChem)	2244	ChEMBL					pharyngeal pumping				fast body movement span				number of offspring				vertex (progeny per day)				heat stress resistance				ATP level				quantity of germline stem cells				triglyceride / fat / lipid content				translocation of DAF-16 to nucleus				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
50 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																																					up	8.6	yes				Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A8 and A10; no significant changes at A1, A4, A12, A14, A16, A18, and A20	up	9.46	yes										up	58.07	yes	A5; Stressor: 35°C; endpoint: mean lifespan	up		yes	A2													up	15.5	yes			DAF-2, DAF-16, AAK-2/AMPK, PAR-4/LKB1, IIS-pathway, and dietary restriction-like pathway	Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
200 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																																					up	12.95	yes				Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	CF1038 [daf-16(mu86)]	20°C																																					none		no				Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	CB1370 [daf-2(e1370)]	20°C																																					up	3.2	yes				Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																																	none			A1							Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	DA1116 [eat-2(ad1116)]	20°C																																					none		no				Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	20°C																																					up	22.35	yes				Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	MQ887 [isp-1(qm150)]	20°C																																					none		no				Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	CB4876 [clk-1(e2519)]	20°C																																					none		no				Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	RB754 [aak-2(ok524)]	20°C																																					none		no				Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	KK184 [par-4(it47)]	20°C																																					none		no				Wan QL, Zheng SQ, Wu GS, Luo HR (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol 48, 499-506.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUdR	N2 (wild type)	20°C																	up	27,4	yes	A5; stressor: 35°C; endpoint: mean survival									down		yes						up	14,2	yes	mean of 3 independent trials	A1; upregulation of acs-2, ech-1.2, cpt-5, lips-17, fard-1, sod-3,lipl-4		Huang, X. B., Mu, X. H., Wan, Q. L., He, X. M., Wu, G. S., & Luo, H. R. (2017). Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PloS one, 12(9).
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar		N2 (wild type)	25°C									none		no		none		no										down		yes																Huang, X. B., Mu, X. H., Wan, Q. L., He, X. M., Wu, G. S., & Luo, H. R. (2017). Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PloS one, 12(9).
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUdR	CF1903 [glp-1(e2144)]	20°C																	none		no	A5; stressor: 35°C; endpoint: mean survival									none		no						none		no	25°C exposure from L1-L4			Huang, X. B., Mu, X. H., Wan, Q. L., He, X. M., Wu, G. S., & Luo, H. R. (2017). Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PloS one, 12(9).
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUdR	CF1038 [daf-16(mu86)]	20°C																	none		no	A5; stressor: 35°C; endpoint: mean survival									none		no						none		no				Huang, X. B., Mu, X. H., Wan, Q. L., He, X. M., Wu, G. S., & Luo, H. R. (2017). Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PloS one, 12(9).
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUdR	AA86 [daf-12(rh61rh411)]	20°C																	none		no	A5; stressor: 35°C; endpoint: mean survival									none		no						none		no				Huang, X. B., Mu, X. H., Wan, Q. L., He, X. M., Wu, G. S., & Luo, H. R. (2017). Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PloS one, 12(9).
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUdR	AA89 [daf-12(rh274)]	20°C																	none		no	A5; stressor: 35°C; endpoint: mean survival									none		no						none		no				Huang, X. B., Mu, X. H., Wan, Q. L., He, X. M., Wu, G. S., & Luo, H. R. (2017). Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PloS one, 12(9).
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUdR	CF1880 [glp-1(e2141); daf-16(mu86)]	20°C																																					none		no	25°C exposure from L1-L4			Huang, X. B., Mu, X. H., Wan, Q. L., He, X. M., Wu, G. S., & Luo, H. R. (2017). Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PloS one, 12(9).
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUdR	CF2248 {glp-1(e2141); daf-12(rh61rh411); daf-16(mu86); muEx158 [daf-16AM::GFP + sur-5p::GFP]}	20°C																																					none		no	25°C exposure from L1-L4			Huang, X. B., Mu, X. H., Wan, Q. L., He, X. M., Wu, G. S., & Luo, H. R. (2017). Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PloS one, 12(9).
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUdR	unknown strain; genotype: [glp-1(e2141); daf-12(rh61rh411)]	20°C																																					none		no	25°C exposure from L1-L4			Huang, X. B., Mu, X. H., Wan, Q. L., He, X. M., Wu, G. S., & Luo, H. R. (2017). Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PloS one, 12(9).