Compound ID 87 (prev - next)

Name: Astragalan (Astragalus membranaceus polysaccharide) (103026223) (edit)

26 entries:

Treatment	Astragalan (Astragalus membranaceus polysaccharide)						cognitive function				healthspan biomarkers				lifespan				Transcriptome	Target	Reference
CID (PubChem)	103026223	ChEMBL					neuronal survival / integrity				quantity of polyQ aggregates				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
0.25 mg/ml	whole life; start: L1	OP50	liquid S-medium		AM141 {rmIs133 [unc-54p::Q40::YFP]}	20°C					none		no	24 h, 48 h, 72 h and 96 h after exposure start							Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: L1	OP50	liquid S-medium		AM141 {rmIs133 [unc-54p::Q40::YFP]}	20°C					none		no	24 h, 48 h, 72 h and 96 h after exposure start							Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
2.5 mg/ml	whole life; start: L1	OP50	liquid S-medium		AM141 {rmIs133 [unc-54p::Q40::YFP]}	20°C					none		no	24 h, 48 h, 72 h and 96 h after exposure start							Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
5.0 mg/ml	whole life; start: L1	OP50	liquid S-medium		AM141 {rmIs133 [unc-54p::Q40::YFP]}	20°C					down		yes	significant at 48 h, 72 h and 96 h after exposure start; unchanged after 24 h							Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
0.25 mg/ml	whole life; start: L1	OP50	liquid S-medium		HA759 {rtIs11 [osm-10p::GFP + osm-10p::HtnQ150 + dpy-20(+)]}	15°C	none		no	A1; survival of ASH neurons during polyQ-mediated neurodegeneration											Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: L1	OP50	liquid S-medium		HA759 {rtIs11 [osm-10p::GFP + osm-10p::HtnQ150 + dpy-20(+)]}	15°C	up		yes	A1; survival of ASH neurons during polyQ-mediated neurodegeneration											Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
2.5 mg/ml	whole life; start: L1	OP50	liquid S-medium		HA759 {rtIs11 [osm-10p::GFP + osm-10p::HtnQ150 + dpy-20(+)]}	15°C	up		yes	A1; survival of ASH neurons during polyQ-mediated neurodegeneration											Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	N2 (wild type)	20°C									up		yes			DAF-16	Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
2.5 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	N2 (wild type)	20°C									up		yes				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	HA759 {rtIs11 [osm-10p::GFP + osm-10p::HtnQ150 + dpy-20(+)]}	20°C									up		yes				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
2.5 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	HA759 {rtIs11 [osm-10p::GFP + osm-10p::HtnQ150 + dpy-20(+)]}	20°C									up		yes				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	AM141 {rmIs133 [unc-54p::Q40::YFP]}	20°C									up		yes				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
2.5 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	AM141 {rmIs133 [unc-54p::Q40::YFP]}	20°C									up		yes				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	CB1370 [daf-2(e1370)]	15°C									up		yes				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
2.5 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	CB1370 [daf-2(e1370)]	15°C									up		yes				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	TJ1052 [age-1(hx546)]	20°C									up		yes				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
2.5 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	TJ1052 [age-1(hx546)]	20°C									up		yes				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	DR26 [daf-16(m26)]	20°C									none		no				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
2.5 mg/ml	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizine, FUDR	DR26 [daf-16(m26)]	20°C									none		no				Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: L1	OP50	liquid S-medium		N2 (wild type)	20°C													A1; upregulation of scl-20, dct-5, col-84, grd-4, spp-20		Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: L1	OP50	liquid S-medium		HA759 {rtIs11 [osm-10p::GFP + osm-10p::HtnQ150 + dpy-20(+)]}	20°C													A1; upregulation of scl-20, dct-5, col-84, grd-4, spp-20		Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: L1	OP50	liquid S-medium		AM141 {rmIs133 [unc-54p::Q40::YFP]}	20°C													A1; upregulation of scl-20, dct-5, col-84, grd-4, spp-20		Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.
1.0 mg/ml	whole life; start: L1	OP50	liquid S-medium		DR26 [daf-16(m26)]	20°C													A1: no change in expression of scl-20		Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, Cao Z, Tunnacliffe A, Huang Z (2012) Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J 441, 417-424. doi: 10.1042/BJ20110621.