Compound ID 90   (prev - next)

Name: BMS-754807 (24785538) (edit)

7 entries:
TreatmentBMS-754807healthspan biomarkersTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)24785538ChEMBLactivity / quantity / expression of HSPs
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notes
150 µM3 h at A1 and 3 h at A2HT115 (DE3)NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°CnonenoA2; pre-exposed to 33°C for 3 h; expression of hsp-16.2 measured via western blotEl-Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E (2014) A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell 13, 165-174.
300 µM3 h at A1 and 3 h at A2HT115 (DE3)NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°CnonenoA2; pre-exposed to 33°C for 3 h; expression of hsp-16.2 measured via western blotEl-Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E (2014) A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell 13, 165-174.
600 µM3 h at A1 and 3 h at A2HT115 (DE3)NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°CnonenoA2; pre-exposed to 33°C for 3 h; expression of hsp-16.2 measured via western blotEl-Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E (2014) A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell 13, 165-174.
900 µM3 h at A1 and 3 h at A2HT115 (DE3)NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°CnonenoA2; pre-exposed to 33°C for 3 h; expression of hsp-16.2 measured via western blotEl-Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E (2014) A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell 13, 165-174.