Compound ID 95 (prev - next)

Name: Bacopa monnieri aqueous extract (edit)

12 entries:

Treatment	Bacopa monnieri aqueous extract						cognitive function				physical function				physiological function								healthspan biomarkers								lifespan												Target	Reference
CID (PubChem)		ChEMBL					chemotaxis				pharyngeal pumping				heat stress resistance				oxidative stress resistance				ROS level				activity / quantity / expression of HSPs				mean lifespan				maximum lifespan				minimum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
0.001 mg/ml	whole life; start: L1	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A5; attractant: 1M sodium acetate	up		yes	A3, A5, A7, A9, and A11	up	25.37	yes	A2; stressor: 37°C; endpoint: mean lifespan; similar results in median lifespan	up	56.01	yes	A2; stressor: 10 mM paraquat; endpoint: mean lifespan; similar results in median lifespan	down		yes	A2; exposed to 37°C; measured via H2DCF-DA					up	3.90	no		none		n.d.		up	21.18	n.d.		HSP-16.2	Phulara SC, Shukla V, Tiwari S, Pandey R (2015) Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag 11, 410-416.
0.01 mg/ml	whole life; start: L1	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A5; attractant: 1M sodium acetate	up		yes	A3, A5, A7, A9, and A11	up	20.27	yes	A2; stressor: 37°C; endpoint: mean lifespan; similar results in median lifespan	up	68.22	yes	A2; stressor: 10 mM paraquat; endpoint: mean lifespan; similar results in median lifespan	down		yes	A2; exposed to 37°C; measured via H2DCF-DA					up	6.05	no		up	8.33	n.d.		up	18.18	n.d.			Phulara SC, Shukla V, Tiwari S, Pandey R (2015) Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag 11, 410-416.
0.1 mg/ml	whole life; start: L1	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A5; attractant: 1M sodium acetate	up		yes	A5, A7, A9, and A11; unchanged at A3	up	22.50	yes	A2; stressor: 37°C; endpoint: mean lifespan; similar results in median lifespan	up	79.71	yes	A2; stressor: 10 mM paraquat; endpoint: mean lifespan; similar results in median lifespan	down		yes	A2; exposed to 37°C; measured via H2DCF-DA					up	4.07	no		up	4.17	n.d.		up	18.18	n.d.			Phulara SC, Shukla V, Tiwari S, Pandey R (2015) Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag 11, 410-416.
0.001 mg/ml	whole life; start: L1	OP50	NGM agar	FUDR	TK22 [mev-1(kn1)]	20°C																									up	14.55	yes		up	6.10	n.d.		up	53.57	n.d.			Phulara SC, Shukla V, Tiwari S, Pandey R (2015) Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag 11, 410-416.
0.01 mg/ml	whole life; start: L1	OP50	NGM agar	FUDR	TK22 [mev-1(kn1)]	20°C																									up	13.79	yes		up	6.10	n.d.		up	25.00	n.d.			Phulara SC, Shukla V, Tiwari S, Pandey R (2015) Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag 11, 410-416.
0.1 mg/ml	whole life; start: L1	OP50	NGM agar	FUDR	TK22 [mev-1(kn1)]	20°C																									up	25.39	yes		up	3.66	n.d.		up	50.00	n.d.			Phulara SC, Shukla V, Tiwari S, Pandey R (2015) Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag 11, 410-416.
0.001 mg/ml	48 h; start: A1	OP50	NGM agar		CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}	20°C																					up		yes	A4; pre-exposed to 37°C for 2 h														Phulara SC, Shukla V, Tiwari S, Pandey R (2015) Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag 11, 410-416.
0.01 mg/ml	48 h; start: A1	OP50	NGM agar		CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}	20°C																					up		yes	A4; pre-exposed to 37°C for 2 h														Phulara SC, Shukla V, Tiwari S, Pandey R (2015) Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag 11, 410-416.
0.1 mg/ml	48 h; start: A1	OP50	NGM agar		CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}	20°C																					up		yes	A4; pre-exposed to 37°C for 2 h														Phulara SC, Shukla V, Tiwari S, Pandey R (2015) Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag 11, 410-416.