Compound ID 96 (prev - next)

Name: Baicalein (5281605) (edit)

13 entries:

Treatment	Baicalein						physical function				physiological function								healthspan biomarkers				lifespan								Target	Reference
CID (PubChem)	5281605	ChEMBL					pharyngeal pumping				heat stress resistance				arsenite stress resistance				translocation of DAF-16 to nucleus				median lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
25 µM	whole life; start: L4/A1	OP50-1	liquid NGM	BSA, streptomycin	N2 (wild type)	25°C																	up	8.69	no		up	7.00	no			Havermann S, Humpf HU, Wätjen W (2016) Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia 113, 123-127.
50 µM	whole life; start: L4/A1	OP50-1	liquid NGM	BSA, streptomycin	N2 (wild type)	25°C																	up	17.39	yes		up	17.00	yes			Havermann S, Humpf HU, Wätjen W (2016) Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia 113, 123-127.
100 µM	whole life; start: L4/A1	OP50-1	liquid NGM	BSA, streptomycin	N2 (wild type)	25°C	none		no	A5, A10, and A15													up	56.52	yes						SKN-1	Havermann S, Humpf HU, Wätjen W (2016) Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia 113, 123-127.
100 µM	whole life; start: L4/A1	HT115 (DE3)	liquid NGM	BSA, IPTG, ampicillin, tetracycline	N2 (wild type)	25°C																	up	13.00	yes		up	39.00	yes			Havermann S, Humpf HU, Wätjen W (2016) Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia 113, 123-127.
100 µM	whole life; start: L4/A1	HT115 (DE3) with RNAi-vector against skn-1	liquid NGM	BSA, IPTG, ampicillin, tetracycline	N2 (wild type)	25°C																	none		no		up	6.00	no			Havermann S, Humpf HU, Wätjen W (2016) Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia 113, 123-127.
100 µM	whole life; start: L4/A1	HT115 (DE3)	liquid NGM	BSA, IPTG, ampicillin, tetracycline	CF1038 [daf-16(mu86)]	25°C																	up	15.78	yes							Havermann S, Humpf HU, Wätjen W (2016) Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia 113, 123-127.
100 µM	whole life; start: L4/A1	HT115 (DE3) with RNAi-vector against skn-1	liquid NGM	BSA, IPTG, ampicillin, tetracycline	CF1038 [daf-16(mu86)]	25°C																	up	5.26	no							Havermann S, Humpf HU, Wätjen W (2016) Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia 113, 123-127.
100 µM	whole life; start: L4/A1	OP50-1	liquid NGM	BSA, streptomycin	N2 (wild type)	20°C					up	11.00	yes	A3; stressor: 37°C; endpoint: survival																		Havermann S, Humpf HU, Wätjen W (2016) Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia 113, 123-127.
100 µM	whole life; start: L4/A1	OP50-1	liquid NGM	BSA, streptomycin, FUDR	N2 (wild type)	20°C									up	16.00	yes	A3; stressor: 5 mM sodium arsenite; endpoint: survival														Havermann S, Humpf HU, Wätjen W (2016) Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia 113, 123-127.
100 µM	1 h; start: L4/A1	OP50-1	liquid NGM	BSA, streptomycin, FUDR	TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C													none		no	A1										Havermann S, Humpf HU, Wätjen W (2016) Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia 113, 123-127.