Phenotype GroupPhenotypeCompounds
physiological functionoxidative stress resistance0,1,2,3,4,5,6,8,18,21,35,47,48,53,58,59,60,62,63,64,70,71,72,73,74,75,76,77,78,79,80,81,82,85,88,89,91,92,93,95,98,103,106,108,109,115,116,117,119,120,121,122,125,126,127,129,133,134,136,138,139,141,145,146,147,149,150,152,156,157,158,160,161,162,163,165,166,167,168,169,175,176,178,179,182,183,185,186,187,189,190,191,192,193,197,199,202,204,205,210,211,213,214,215,217,218,220,221,222,225,227,228,229,230,231,234,236,237,238,239,240,241,243,244,245,246,247,253,254,255,256,257,258,259,263,264,268,269,276,277,279,280,281,282,283,284,285,287,288,289,290,291,294,295,296,298,299,300,302,305,316,318,319,320,324,325,326,329,332,334,335,336,337,342,343,344,345,346,350,354,355,356,357,358,360,366,367,368,369,372,373,374,375,376,377,378,383,384,385,389,390,393,395,404,409,411,417,425,435,439,440,441
physiological functionheat stress resistance3,4,6,7,9,10,11,12,13,14,15,16,17,19,23,25,26,27,28,29,30,31,32,33,34,37,38,39,40,41,42,43,44,45,49,51,52,55,56,57,59,60,62,63,64,72,73,78,82,83,84,86,88,89,95,96,97,100,101,102,103,104,106,107,108,114,116,118,121,122,124,125,128,131,132,134,137,145,146,148,150,152,154,162,164,165,167,169,171,172,174,175,176,178,179,181,184,186,187,188,192,194,195,197,198,199,200,202,207,208,212,219,222,223,227,231,232,237,242,243,244,246,248,252,257,258,259,262,263,266,267,271,272,273,275,277,278,279,281,282,285,288,289,290,293,296,297,298,299,300,302,305,318,319,320,324,325,326,330,332,333,335,336,340,342,343,350,354,357,358,360,362,364,365,368,372,373,375,376,381,383,384,386,387,389,390,391,393,394,401,404,406,409,415,416,417,424,429,431,435,438
physiological functionpathogen stress resistance78,125,134,159,265,325,326
physiological functionUV stress resistance78,79,100,134,159,165,197,252,266,298,364,372,402,403,404,414,416,438
physiological functionosmotic stress resistance89,108,121,134,285,299,409
physiological functionarsenite stress resistance96
physiological functionmetal stress resistance100
physiological functionsalt stress resistance100
lifespanmean lifespan0,1,2,3,4,5,6,8,14,18,20,21,22,24,35,36,46,47,48,50,53,54,58,59,60,61,62,65,66,67,68,69,70,71,73,74,75,76,77,78,80,81,82,83,84,85,86,87,88,89,91,92,93,95,98,100,103,104,105,106,107,108,109,110,111,112,113,115,116,119,121,122,124,125,126,129,133,134,135,136,138,139,141,143,144,147,149,153,154,155,156,157,158,160,161,162,165,166,167,168,169,170,171,174,175,176,177,178,179,182,183,184,185,186,187,189,190,191,192,193,195,196,197,198,199,200,201,202,203,204,206,207,210,211,213,217,218,219,220,221,222,224,225,227,229,230,231,232,234,235,236,237,238,239,240,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257,258,259,262,263,266,267,268,269,271,272,273,275,276,278,279,280,281,282,283,284,285,287,288,289,290,291,292,295,296,298,299,302,305,316,318,319,320,321,322,323,324,325,326,327,328,330,332,334,335,336,337,338,339,343,344,346,347,348,349,350,353,354,355,356,357,358,359,360,361,362,363,365,366,368,372,373,374,375,376,378,379,380,381,382,383,384,385,386,387,389,390,391,393,394,396,397,398,400,401,404,406,408,409,410,412,416,417,419,420,421,422,423,424,425,427,429,431,434,435,436,437,438
lifespanmaximum lifespan8,48,60,70,71,78,79,82,94,95,96,99,106,108,109,114,119,121,123,125,136,143,145,146,153,154,155,156,162,165,170,171,175,179,180,187,195,196,197,198,209,224,225,228,235,243,248,249,250,251,266,267,271,272,273,275,285,290,296,298,299,300,302,305,318,327,328,331,333,339,340,343,357,360,362,363,365,372,375,379,382,383,391,393,396,397,399,402,403,404,406,408,410,415,416,417,423,426,429,431,434,435,438
lifespanminimum lifespan8,48,95,154,165,248,296,298,391,406
lifespanmedian lifespan70,71,94,96,99,114,119,122,123,134,135,145,146,154,155,169,170,176,179,180,195,199,207,209,227,228,248,249,250,275,277,278,281,285,288,289,290,293,296,300,317,319,320,330,331,332,333,335,340,343,359,360,365,375,377,379,382,385,391,393,394,397,398,399,401,404,406,408,410,415,417,419,420,421,422,424,426,434
lifespansurvival at a given time point159,170,328,339,425
healthspan biomarkersROS level1,3,4,6,8,18,48,59,60,62,65,66,67,76,77,80,81,82,85,88,89,95,100,108,109,114,115,116,117,119,121,134,136,155,159,162,168,173,175,179,182,183,186,189,192,197,204,205,207,214,220,221,225,234,241,243,246,259,262,263,264,266,275,277,278,279,281,282,285,290,294,295,296,299,300,302,305,318,330,343,345,346,350,353,354,357,358,360,364,365,368,372,373,374,375,377,383,390,394,401,404,409,413,414,417,424,425,429,430,431,432,433,441
healthspan biomarkersactivity / quantity / expression of HSPs1,14,48,59,65,66,67,73,76,77,79,80,81,85,89,90,95,106,108,115,119,123,124,135,136,145,146,162,163,165,168,171,173,178,179,182,183,189,192,214,220,221,225,226,232,234,244,251,252,279,295,296,298,302,305,345,346,357,373,383,385,426
healthspan biomarkerstranslocation of DAF-16 to nucleus1,8,48,59,62,76,77,80,81,86,89,96,109,114,116,117,121,125,130,134,145,146,153,156,162,165,174,182,183,187,198,207,220,221,222,231,234,235,243,244,252,263,264,267,277,278,280,281,286,290,294,296,298,300,302,305,343,354,360,368,373,375,384,385,394,401,409,416,417,424,429,431
healthspan biomarkersactivity / quantity / expression of SODs3,21,48,59,60,73,76,77,82,88,89,100,108,109,115,119,121,136,162,168,175,178,182,183,192,202,222,225,243,244,259,266,271,272,273,280,285,290,294,296,299,302,305,318,330,333,340,345,350,354,357,360,365,368,372,373,375,380,383,385,390,404,415,417,425
healthspan biomarkersconcentration of N(6)-Carboxymethyllysine (CML)4,6,237,282
healthspan biomarkersquantity of α-synuclein8,60,136,195,216,343,350,351,352,353,360,391,406,418,422,425,441
healthspan biomarkersquantity of carbonylated proteins18,21,115,155,224,425
healthspan biomarkersquantity of β-Amyloid18,21,134,162,174,192,204,225,252,267,274,290,374,419,420,421
healthspan biomarkersactivity / quantity / expression of CTLs18,21,59,60,82,100,109,114,121,178,185,243,259,266,271,272,273,285,302,305,318,350,357,373,375,380,390,404,417
healthspan biomarkersproteasomal activity18,89,119,128,164,172,194,302,305
healthspan biomarkerstranslocation of SKN-1 to nucleus18,76,77,114,116,162,182,183,281,296,302,305,377,398,409,429,431
healthspan biomarkerstriglyceride / fat / lipid content21,48,86,88,109,119,122,155,167,176,243,245,261,332,350,353,360,367,369,370,371,375,383,395,398,407,417,425
healthspan biomarkersautofluorescence (age pigment / lipofuscin)59,60,76,77,78,88,89,94,106,121,162,171,175,182,183,184,186,195,197,222,246,259,266,275,279,281,290,296,299,317,318,330,350,358,360,362,368,372,373,375,376,383,389,390,391,394,398,401,404,406,416,417,422,424,425
healthspan biomarkersactivity / quantity / expression of GSTs59,60,71,76,77,88,89,119,124,136,140,150,151,152,162,175,182,183,192,244,260,279,280,290,296,301,302,303,304,305,306,307,308,309,310,311,312,313,314,315,330,333,340,345,346,350,360,365,368,373,385,398,412,415,442,443,444
healthspan biomarkersactivity / quantity / expression of UGTs71
healthspan biomarkersoxygen consumption rate (OCR)82,109,228,317,336,346,427
healthspan biomarkersGSH level82,109,155,156,243,318,373,390,417
healthspan biomarkersATP level86,123,155,224,231,285,293,346
healthspan biomarkersquantity of germline stem cells86
healthspan biomarkersquantity of polyQ aggregates87,89,168,187,202,251,252,350,362
healthspan biomarkersthiol level89,156
healthspan biomarkersactivity / quantity / expression of GCS-189,119
healthspan biomarkersactivity / quantity / expression of GPDHs89
healthspan biomarkersactivity / quantity / expression of GSH-PX100,243,375,417
healthspan biomarkerslevel of 4-HNE106
healthspan biomarkersAMP:ATP ratio109
healthspan biomarkersphosphofructokinase activity109
healthspan biomarkerslipase activity109
healthspan biomarkershexokinase activity109
healthspan biomarkerspyruvate kinase activity109
healthspan biomarkerslevel of autophagy109,224,292,296,341,346,441
healthspan biomarkersantioxidative capacity122,167,176,332
healthspan biomarkersmitochondrial content/quality123,285,293,336,346
healthspan biomarkersintestinal bacteria colonization135
healthspan biomarkersphosphorylation level of PMK-1135
healthspan biomarkersMDA level154,243,248,259,266,271,272,273,372,375,390,404,417
healthspan biomarkersmuscle integrity179,202,336,346,359
healthspan biomarkersactivity of acetylcholinesterase192,204,360,374
healthspan biomarkersmitochondrial DNA copy number224
healthspan biomarkersmitochondrial ROS production228
healthspan biomarkersaxonal HTT (exon-1 huntingtin)-aggregates233,405
healthspan biomarkersaxonal dystrophy233,392,405
healthspan biomarkersquantity of apoptotic cells246,425
healthspan biomarkerslactate level285,293
healthspan biomarkerspyruvate level285,293
healthspan biomarkersmitochondrial membrane potential285,293
healthspan biomarkersF3-isoprostane level317
healthspan biomarkersmitochondrial DNA (mtDNA) integrity317
healthspan biomarkersactivity / quantity / expression of CYPs333,340,365,415
healthspan biomarkersacetylcholine level360
healthspan biomarkersactivity / quantity / expression of SKN-1368
cognitive functionchemotaxis8,48,88,95,136,145,146,162,175,179,192,262,267,350,360,365,419,420,421,425
cognitive functionmechanical sensory / touch response65,66,67,130,174,233,274,392,405
cognitive functionneuronal survival / integrity87,195,286,343,391,406,441
cognitive functionaldicarb resistance88
cognitive functionmemory134,422
cognitive functionquantity of D-type GABAergic motorneurons186
physical functionpharyngeal pumping8,14,18,21,48,59,60,69,76,77,79,86,88,89,95,96,106,108,109,115,119,121,122,145,146,154,155,159,162,167,168,175,176,178,179,182,183,186,187,192,213,219,222,248,259,261,263,275,277,281,285,292,296,299,317,318,325,326,332,336,338,343,346,347,348,349,350,354,357,359,360,362,365,366,368,373,376,377,380,384,385,389,390,394,398,401,402,403,409,424,425
physical functionlocomotion in liquid media14,82,103,186,192,195,202,258,275,280,296,336,343,360,373,383,385,391,398,400,406,409,425,429,431
physical functionlocomotion on solid media14,18,21,62,65,66,67,69,78,88,108,119,121,123,134,136,145,146,155,162,167,170,171,177,178,179,186,192,200,202,204,219,222,224,225,226,243,246,251,252,266,267,270,277,285,290,292,318,324,325,326,336,338,339,346,347,348,349,353,357,358,359,360,365,372,374,375,376,377,381,386,387,388,389,390,399,404,413,416,417,419,420,421,422,428
physical functionduration of defecation cycles18,21,186
physical functionbody length / growth rate59,60,76,77,89,108,115,119,121,122,124,142,154,155,162,167,168,175,176,178,186,197,222,246,248,266,277,281,296,302,305,332,343,345,350,357,358,360,368,372,376,377,389,394,401,404,412,416,424
physical functionfast body movement span86,125,170,231,267,339
physical functionfast pharyngeal pumping span170,339
physical functionpharyngeal total span170,177,339,362
physical functionbody wave number195,391,406
physical functionfood consumption271,272,273,302,305
reproductive functionnumber of offspring18,21,59,61,65,66,67,71,76,77,78,83,84,86,88,89,103,108,119,121,122,123,124,134,142,145,146,154,162,167,169,170,175,176,178,186,192,199,213,222,227,242,245,248,251,258,266,275,277,281,285,288,289,296,299,302,305,319,320,325,326,332,333,335,340,343,346,350,353,357,358,360,362,365,368,372,373,375,376,377,384,385,389,394,401,404,409,412,415,417,424,438
reproductive functionspeed of larval development18,21,123,170,242,251,258,325,343,346,377,398,409,438
reproductive functionquantity of dauer formation18,21,125,219
reproductive functionquantity of embryonic lethality21
reproductive functionvertex (progeny per day)60,86,88,89,103,115,119,122,124,154,170,178,248,275,332,343,373,377,394,401,412,424
reproductive functionquantity of early reproduction61,121,122,123,142,167,176,187,259,285,296,302,305,332,365,398,417,438
reproductive functiononset of egg laying122,145,146,167,176,251,296,332,343
reproductive functionquantity of late reproduction123,170,187,222,259,296,302,305,375,398,417,438
reproductive functionreproductive total span145,146,170,175,242,245,326,339,350,362
reproductive functionreproductive growth span170
reproductive functionquantity of internal hatch339