Compound ID 109 (prev - next)

Name: Buckwheat trypsin inhibitor (recombinant) (edit)

11 entries:

Treatment	Buckwheat trypsin inhibitor (recombinant)						physical function				physiological function				healthspan biomarkers																																																				lifespan								Transcriptome	Target	Reference
CID (PubChem)		ChEMBL					pharyngeal pumping				oxidative stress resistance				activity / quantity / expression of SODs				activity / quantity / expression of CTLs				GSH level				AMP:ATP ratio				ROS level				triglyceride / fat / lipid content				oxygen consumption rate (OCR)				phosphofructokinase activity				lipase activity				hexokinase activity				pyruvate kinase activity				level of autophagy				translocation of DAF-16 to nucleus				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
2.5 µM	whole life; start: L4/A1	OP50	NGM agar	FUDR	N2 (wild type)	20°C																																																													up	7.51	yes		up	4.78	n.d.				Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71.
5 µM	whole life; start: L4/A1	OP50	NGM agar	FUDR	N2 (wild type)	20°C																																																													up	15.61	yes		up	11.40	n.d.				Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71.
10 µM	whole life; start: L4/A1	OP50	NGM agar	FUDR	N2 (wild type)	20°C	none		no	A1/A2	up	16.30	yes	A6; stressor: 240 μM juglone; endpoint: mean survival; 23.20 % increase in maximum survival	variable		yes	increased by 154 % in A1; decreased by -25.3 % in A2, by -60.3 in A3, by -29.4 in A4, and by -12.5 in A7	variable		yes	increased by 49 % in A1 and by 12.9 % in A2; decreased by -32.8 % in A3, by -18.7 in A4, and by -16.7 in A7	variable		yes	increased by 29 % in A1, by 38.4 % in A2, and by 95.2 % in A3; decreased by -39.5 in A4 and by -41.8 in A7	up	57.00	yes	A2	variable		yes	increased by 60 % in A1; decreased by -38 % in A3, -20 % in A4, and -20 % in A7; no significant change in A2; measured via H2-DCF-DA	down	-15.40	yes	measured via oil red	up	25.00	yes	A1	down	-47.6	yes	young adults	up	28.00	yes	young adults	down	-7.90	yes	young adults	up		yes	young adults	up		n.d.						up	23.70	yes		up	16.54	n.d.		down-regulation of daf-2, age-1, akt-1, and genes involved in glycolytic metabolism (Y71H10A.1, C50F4.2, F25H5.3, and ZK593.1); up-regulation of daf-16, sod-3, lipl-4, and gsh-px	insulin/IGF-1 signaling	Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71.
10 µM	whole life; start: L4/A1	OP50	NGM agar	1 mM NAC, FUDR	N2 (wild type)	20°C																																																													up	7.83	no		up	1.02	n.d.				Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71.
10 µM	whole life; start: L4/A1	OP50	NGM agar	FUDR	CF1038 [daf-16(mu86)]	20°C																																																													up	8.78	no		up	6.56	n.d.				Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71.
10 µM	whole life; start: L4/A1	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																																																									up		n.d.												Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71.
10 µM	whole life; start: L4/A1	OP50	NGM agar		DA2123 {adls2122 [lgg-1p::GFP::lgg-1 + rol-6(su1006)]}	20°C																																																																							Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71.
10 µM	whole life; start: L4/A1	OP50	NGM agar	FUDR	DR1572 [daf-2(e1368)]	20°C																									none		no	A1; measured via H2-DCF-DA																																	up	1.15	no		up	1.08	n.d.				Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71.