| Treatment | Camellia tenuifolia seed oil | physiological function | healthspan biomarkers | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | oxidative stress resistance | ROS level | translocation of DAF-16 to nucleus | ||||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 0.01 % | whole life; start: L1 | OP50 | liquid S-medium | N2 (wild type) | 20°C | up | 74.00 | yes | A1; stressor: 250 µM juglone for 2.5 h; endpoint: survival | down | yes | A1; measured via H2DCF-DA | DAF-16 | Wei CC, Yen PL, Chang ST, Cheng PL, Lo YC, Liao VH (2016) Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans. PLoS One 11, e0157195. | ||||||||||
| 0.1 % | whole life; start: L1 | OP50 | liquid S-medium | N2 (wild type) | 20°C | up | 78.00 | yes | A1; stressor: 250 µM juglone for 2.5 h; endpoint: survival | Wei CC, Yen PL, Chang ST, Cheng PL, Lo YC, Liao VH (2016) Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans. PLoS One 11, e0157195. | ||||||||||||||
| 0.01 % | whole life; start: L1 | OP50 | liquid S-medium | GR1307 [daf-16(mgDf50)] | 20°C | none | no | A1; stressor: 250 µM juglone for 2.5 h; endpoint: survival | Wei CC, Yen PL, Chang ST, Cheng PL, Lo YC, Liao VH (2016) Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans. PLoS One 11, e0157195. | |||||||||||||||
| 0.01 % | whole life; start: L1 | OP50 | liquid S-medium | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | 241.66 | n.d. | A1; pre-exposure to 50 μM juglonefor 5 min | Wei CC, Yen PL, Chang ST, Cheng PL, Lo YC, Liao VH (2016) Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans. PLoS One 11, e0157195. | ||||||||||||||