Compound ID 162   (prev - next)

Name: Epigallocatechin gallate (EGCG) (65064) (edit)

48 entries:
TreatmentEpigallocatechin gallate (EGCG)cognitive functionphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)65064ChEMBLchemotaxispharyngeal pumpinglocomotion on solid mediabody length / growth ratenumber of offspringheat stress resistanceoxidative stress resistanceautofluorescence (age pigment / lipofuscin)ROS levelactivity / quantity / expression of SODstranslocation of SKN-1 to nucleusactivity / quantity / expression of HSPsactivity / quantity / expression of HSPsactivity / quantity / expression of GSTsquantity of β-Amyloidtranslocation of DAF-16 to nucleusmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
10 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°CnonenoA2, A4, A6, A8downnoL4/A1, measurement via DCF-DABrown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
25 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°CupyesA5; no significant changes at A1; attractant: diacetylupyesA8; no significant changes in A2, A4, A6upyesA16; no significant changes in A12downyesL4/A1, measurement via DCF-DAup4,8noup4,76noBrown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
50 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°CupyesA6 & A8; no significant changes in A2 & A4downyesL4/A1, measurement via DCF-DABrown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
100 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°CupyesA4 & A6; no significant changes in A2 & A8downyesL4/A1, measurement via DCF-DABrown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
25 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°CdownnoA5, measurement via DCF-DABrown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
25 µMwhole life; start: L1OP50NGM agarGR1307 [daf-16(mgDf50)]20°CdownnoL4/A1, measurement via DCF-DAnone8,6nonone0noBrown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
25 µMwhole life; start: egg stageOP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°CupnoL3; temperature shift to 23°C prior analysing paralysisBrown, M. K., Evans, J. L., & Luo, Y. (2006). Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacology Biochemistry and Behavior, 85(3), 620-628.
0.1 µg/mlwhole life; start: A1OP50NGM agarFUDRN2 (wild type)20°Cup13.1yesA3; Stressor: 35°C; endpoint: mean lifespan; percentual change of maximum survival = 11.76up172.9yesA3; Stressor: 500 µM juglone; endpoint: mean lifespandownyesA3; measured with H2DCF-DA; similar change during juglone treatmentdown-1.8noAlso no life extension at 25°C (data not shown)sod-3, hsp-16.2, and skn-1Zhang L, Jie G, Zhang J, Zhao B (2009) Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress. Free Radic Biol Med 46, 414-421.
1 µg/mlwhole life; start: A1OP50NGM agarFUDRN2 (wild type)20°Cup8.0yesA3; Stressor: 35°C; endpoint: mean lifespan; percentual change of maximum survival = 11.76up177.7yesA3; Stressor: 500 µM juglone; endpoint: mean lifespanup1.7noAlso no life extension at 25°C (data not shown)Zhang L, Jie G, Zhang J, Zhao B (2009) Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress. Free Radic Biol Med 46, 414-421.
10 µg/mlwhole life; start: A1OP50NGM agarFUDRN2 (wild type)20°Cup11.8yesA3; Stressor: 35°C; endpoint: mean lifespan; percentual change of maximum survival = 11.76up88.5yesA3; Stressor: 500 µM juglone; endpoint: mean lifespanup1.8noAlso no life extension at 25°C (data not shown)Zhang L, Jie G, Zhang J, Zhao B (2009) Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress. Free Radic Biol Med 46, 414-421.
0.1 µg/mlwhole life; start: A1OP50NGM agarFUDRCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°Cup49.00yesA3; measured via fluorescence; similar changes also at A5, A7, A9Zhang L, Jie G, Zhang J, Zhao B (2009) Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress. Free Radic Biol Med 46, 414-421.
0.1 µg/mlwhole life; start: A1OP50NGM agarFUDRCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°Cup11.9yesA4; after heat shock (35°C for 1 h) and recovery (24h); measured via fluorescenceZhang L, Jie G, Zhang J, Zhao B (2009) Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress. Free Radic Biol Med 46, 414-421.
220 µMwhole life; start: A1OP50NGM agarN2 (wild type)20°Cup10.14yesAbbas S, Wink M (2009) Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta Med 75, 216-221. doi: 10.1055/s-0028-1088378.
220 µMwhole life; start: L2/L3OP50NGM agarN2 (wild type)20°Cup289.00yesA1; Stressor: 80 µM juglone for 24 hdown-32.57yesA2; measured with DCF-DA assayAbbas S, Wink M (2009) Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta Med 75, 216-221. doi: 10.1055/s-0028-1088378.
220 µMwhole life; start: L2/L3OP50NGM agarTJ375 {gpIs1 [hsp-16.2p::GFP]}20°Cdown-73.26yesA2; after exposure to EGCG for 48 h and thereafter 20 µM juglone for 24 h; measured via fluorescenceAbbas S, Wink M (2009) Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta Med 75, 216-221. doi: 10.1055/s-0028-1088378.
220 µMwhole life; start: A1OP50NGM agarBA17 [fem-1(hc17)]25°CdownyesA15up14.27yesAbbas S, Wink M (2009) Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta Med 75, 216-221. doi: 10.1055/s-0028-1088378.no
55 µMwhole life; start: A1OP50NGM agarTK22 [mev-1(kn1)]20°Cup16.11yesAbbas S, Wink M (2009) Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta Med 75, 216-221. doi: 10.1055/s-0028-1088378.no
220 µMstart: L2/L3; stop: A1OP50liquid S-mediumN2 (wild type)20°CdownyesA2; 20 µM juglone treatment for 24 h from A1 - A2; only slight (not significant) down regulation without jugloneAbbas S, Wink M (2010) Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway. Phytomedicine 17, 902-909. no
220 µMwhole life; start: L2/L3OP50liquid S-mediumBA17 [fem-1(hc17)]25°CdownyesA15; green fluorescenceAbbas S, Wink M (2010) Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway. Phytomedicine 17, 902-909. no
220 µM1 h; start: L2OP50liquid S-mediumTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°Cupn.d.Abbas S, Wink M (2010) Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway. Phytomedicine 17, 902-909. no
220 µMwhole life; start: L4OP50liquid S-mediumCL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}20°CdownyesA4; significance level was reached by fluorescent staining, but not by RT-PCRAbbas S, Wink M (2010) Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway. Phytomedicine 17, 902-909. no
200 µM48 h; start: unknownOP50NGM agarTJ375 {gpIs1 [hsp-16.2p::GFP]}20°Cdownyespre-treated with 20 µM juglone for 24h; measured via fluorescenceSu S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50.
50 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CdownnoA1up92.35yesA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedown-43.36yesA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
50 µg/mlwhole life; start: L1OP50liquid S-mediumEU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°CupyesA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownyesA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
50 µg/mlwhole life; start: L1OP50liquid S-mediumCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°Cdown-23.82yesA2Azevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
50 µg/mlwhole life; start: L1OP50liquid S-mediumCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°Cdown-81.01yesA2; pre-exposed to jugloneAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
50 µg/mlwhole life; start: L1OP50liquid S-mediumCF1038 [daf-16(mu86)]20°CupyesA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownyesA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
50 µg/mlwhole life; start: L1OP50liquid S-mediumTJ375 {gpIs1 [hsp-16.2p::GFP]}20°Cdown-35.02yesA2; pre-exposed to jugloneAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
25 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°Cup40.8yesA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownyesA1; measured via H2DCF-DADuangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. no
25 µg/mlwhole life; start: L1OP50liquid S-mediumCF1038 [daf-16(mu86)]20°CnonenoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownnoA1; measured via H2DCF-DADuangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. no
25 µg/mlwhole life; start: L1OP50liquid S-mediumEU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°CnonenoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownnoA1; measured via H2DCF-DADuangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. no
25 µg/mlwhole life; start: L1OP50liquid S-mediumTJ375 {gpIs1 [hsp-16.2p::GFP]}20°Cdown-61.91yesA2; pre-exposed to jugloneDuangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. no
25 µg/mlwhole life; start: L1OP50liquid S-mediumCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CupyesA2Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. no
25 µg/mlwhole life; start: L1OP50liquid S-mediumTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°Cup45.95yesA2Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. no
25 µg/mlwhole life; start: L1OP50liquid S-mediumCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CdownnoA2; pre-exposed to jugloneDuangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. no
25 µg/mlwhole life; start: L1OP50liquid S-mediumLD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]}20°CnonenoA2Duangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. no
25 µg/mlwhole life; start: L1OP50liquid S-mediumBA17 [fem-1(hc17)]25°Cdown-21.58yesA16; blue fluorescenceDuangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. no
25 µg/mlwhole life; start: L4OP50NGM agarN2 (wild type)20°CupyesA5, A8, A10; no significant change at A12nonenoA1nonenoDuangjan C, Rangsinth P, Gu X, Wink M, Tencomnao T (2019) Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev 2019, 9012396. no
25 µg/mlwhole life; start: n.d.OP50NGM agarN2 (wild type)20°CupyesA5, A8, A10, A12; not significant at A12upyesstressor: 80 μM juglone; endpoint: survival; 48h of compound treatmentdown-35.43yesmeasured via H2DCF-DA; 48h of compound treatmentDuangjan C, Rangsinth P, Gu X, Zhang S, Wink M, Tencomnao T (2019) Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. Phytomedicine 64, 153061. no
25 µg/mlwhole life; start: n.d.OP50NGM agarTJ375 {gpIs1 [hsp-16.2p::GFP]}20°Cdown-61.91yespre-exposed to juglone; 48h of compound treatmentDuangjan C, Rangsinth P, Gu X, Zhang S, Wink M, Tencomnao T (2019) Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. Phytomedicine 64, 153061. no
25 µg/mlwhole life; start: n.d.OP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°Cupyespre-exposed to juglone; 48h of compound treatmentDuangjan C, Rangsinth P, Gu X, Zhang S, Wink M, Tencomnao T (2019) Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. Phytomedicine 64, 153061. no
25 µg/mlwhole life; start: n.d.OP50NGM agarCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°Cdownnopre-exposed to juglone; 48h of compound treatmentDuangjan C, Rangsinth P, Gu X, Zhang S, Wink M, Tencomnao T (2019) Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. Phytomedicine 64, 153061. no
25 µg/mlwhole life; start: n.d.OP50NGM agarTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°Cupyes72h of compound treatmentDuangjan C, Rangsinth P, Gu X, Zhang S, Wink M, Tencomnao T (2019) Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. Phytomedicine 64, 153061. no
25 µg/mlwhole life; start: n.d.OP50NGM agarEU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°Cnoneno72h of compound treatmentDuangjan C, Rangsinth P, Gu X, Zhang S, Wink M, Tencomnao T (2019) Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. Phytomedicine 64, 153061. no
25 µg/mlwhole life; start: n.d.OP50NGM agarBA17 [fem-1(hc17)]25°CdownyesA16; blue fluorescenceDuangjan C, Rangsinth P, Gu X, Zhang S, Wink M, Tencomnao T (2019) Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. Phytomedicine 64, 153061. no