Compound ID 231 (prev - next)

Name: M084 (n-butyl-[1H]-benzimidazol-2-amine) (284016) (edit)

17 entries:

Treatment	M084 (n-butyl-[1H]-benzimidazol-2-amine)						physical function				physiological function								healthspan biomarkers								lifespan				Transcriptome	Target	Reference
CID (PubChem)	284016	ChEMBL					fast body movement span				heat stress resistance				oxidative stress resistance				ATP level				translocation of DAF-16 to nucleus				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
25 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C																					up		no				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
50 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C																					up	9.10	yes				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes		up	26.85	yes	A5; stressor: 35°C; endpoint: survival	up	23.30	yes	L4/A1; stressor: 5 mM paraquat; endpoint: survival	down		yes	A2; unchanged AMP-level					up	19.10	yes		up-regulation of dve-1, hsp-6, hsp-60, sod-3, dod-3, gst-4, hsp-12.6, hsp-16.1, and hsp-16.2	DAF-16, SIR-2.1, SKN-1	Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
1000 µM	whole life; start: L4	OP50	NGM agar	FUDR	N2 (wild type)	20°C																					up		no				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	whole life; start: L4	OP50	NGM agar	FUDR	DA1116 [eat-2(ad1116)]	20°C																					up	9.90	yes				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	whole life; start: L4	OP50	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	20°C																					none		no				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	whole life; start: L4	OP50	NGM agar	FUDR	MQ887 [isp-1(qm150)]	20°C																					none		no				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	whole life; start: L4	OP50	NGM agar	FUDR	CB4876 [clk-1(e2519)]	20°C																					none		no				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	whole life; start: L4	OP50	NGM agar	FUDR	CB1370 [daf-2(e1370)]	20°C																					none		no				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	whole life; start: L4	OP50	NGM agar	FUDR	CF1038 [daf-16(mu86)]	20°C																					none		no				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	whole life; start: L4	OP50	NGM agar	FUDR	JT9609 [pdk-1(sa680)]	20°C																					none		no				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	whole life; start: L4	OP50	NGM agar	FUDR	EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]	20°C																					none		no				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	whole life; start: L4	OP50	NGM agar	FUDR	RB754 [aak-2(ok524)]	20°C																					none		no				Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.
500 µM	30 min; start: L4	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																	up		n.d.	L4							Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR (2017) Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem 426, 101-109.