| Treatment | Momordica saponin extract | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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| CID (PubChem) | ChEMBL | locomotion on solid media | oxidative stress resistance | heat stress resistance | ROS level | translocation of DAF-16 to nucleus | activity / quantity / expression of SODs | activity / quantity / expression of CTLs | triglyceride / fat / lipid content | GSH level | activity / quantity / expression of GSH-PX | MDA level | mean lifespan | maximum lifespan | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
| 25.09 μg/ml | whole life; start: egg stage | OP50 | NGM agar | N2 (wild type) | 20°C | up | 45 | yes | A1, A5, A9 | up | 20 | yes | A1; stressor: 0.1% H2O2; endpoint: mean survival; similar change with paraquat | up | 11 | yes | A1; stressor: 35°C; endpoint: mean survival | down | -66 | yes | A1; measured via H2DCF-DA | up | 28 | yes | A1 | up | 138 | yes | A1 | down | -25 | yes | A1; endpoint: non-esterified fatty acids | up | yes | A1 | none | no | A1 | down | -38 | yes | A1 | up | 11 | yes | up | yes | A1; upregulation of sod-3, sod-5, ctl-1, ctl-2, hsp-16.1, hsp-16.2 | Lin C, Chen Y, Lin Y, Wang X, Hu L, Cao Y, Chen Y (2020) Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract. Eur J Nutr. | no | |||||||||||||
| 25.09 μg/ml | whole life; start: egg stage | OP50 | NGM agar | TK22 [mev-1(kn1)] | 20°C | up | 10 | yes | A1; stressor: 0.1% H2O2; endpoint: mean survival | A1; stressor: 35°C; endpoint: mean survival | Lin C, Chen Y, Lin Y, Wang X, Hu L, Cao Y, Chen Y (2020) Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract. Eur J Nutr. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| 25.09 μg/ml | whole life; start: egg stage | OP50 | NGM agar | GR1307 [daf-16(mgDf50)] | 20°C | up | 15 | yes | A1; stressor: 0.1% H2O2; endpoint: mean survival | Lin C, Chen Y, Lin Y, Wang X, Hu L, Cao Y, Chen Y (2020) Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract. Eur J Nutr. | no | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| 25.09 μg/ml | whole life; start: egg stage | OP50 | NGM agar | EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]] | 20°C | none | no | A1; stressor: 0.1% H2O2; endpoint: mean survival | Lin C, Chen Y, Lin Y, Wang X, Hu L, Cao Y, Chen Y (2020) Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract. Eur J Nutr. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 25.09 μg/ml | whole life; start: egg stage | OP50 | NGM agar | PS3551 [hsf-1(sy441)] | 20°C | none | no | A1; stressor: 0.1% H2O2; endpoint: mean survival | Lin C, Chen Y, Lin Y, Wang X, Hu L, Cao Y, Chen Y (2020) Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract. Eur J Nutr. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 25.09 μg/ml | whole life; start: egg stage | OP50 | NGM agar | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | none | no | A1 | Lin C, Chen Y, Lin Y, Wang X, Hu L, Cao Y, Chen Y (2020) Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract. Eur J Nutr. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 25.09 μg/ml | whole life; start: egg stage | OP50 | NGM agar | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | yes | A1 | Lin C, Chen Y, Lin Y, Wang X, Hu L, Cao Y, Chen Y (2020) Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract. Eur J Nutr. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||