| Treatment | Silydianin A/B | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 11982272 | ChEMBL | mean lifespan | |||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 10 µM | whole life; start: parental generation | OP50, UV-inactivated | NGM agar | N2 (wild type) | 20°C | up | 5.88 | yes | Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267. | |||||||