Compound ID 60   (prev - next)

Name: Acacetin (5280442) (edit)

13 entries:
TreatmentAcacetinphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)5280442ChEMBLpharyngeal pumpingbody length / growth ratevertex (progeny per day)heat stress resistanceoxidative stress resistanceautofluorescence (age pigment / lipofuscin)ROS levelactivity / quantity / expression of SODsactivity / quantity / expression of CTLsactivity / quantity / expression of GSTsquantity of α-synucleinmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
5 µMwhole life; start: L1OP50NGM agarFUDRN2 (wild type)20°CdownnoA5 and A10nonenoA4 and A8up13.79yesA2; stressor: 37°C for 4 h; endpoint: mean lifespanupyesA2; stressor: 250 µM juglone; endpoint: survivaldownyesA5; measured via H2DCF-DAupyesA2; SOD activityupyesA2; catalase activityup9.86yesupn.d.Asthana J, Mishra BN, Pandey R (2016) Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res 50, 861-874. no
25 µMwhole life; start: L1OP50NGM agarFUDRN2 (wild type)20°CdownnoA5 and A10variantyesslightly decreased in A4 and slightly increased in A8up32.41yesA2; stressor: 37°C for 4 h; endpoint: mean lifespanupyesA2; stressor: 250 µM juglone; endpoint: survivaldownyesA4; blue fluorescencedownyesA5; measured via H2DCF-DAupyesA2; SOD activityupyesA2; catalase activityup26.78yesupn.d.up-regulation of sod-3, gst-4, hsp-16.2, and ctl-1Asthana J, Mishra BN, Pandey R (2016) Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res 50, 861-874. no
50 µMwhole life; start: L1OP50NGM agarFUDRN2 (wild type)20°CdownnoA5 and A10upyesA8; unchanged in A4up18.96yesA2; stressor: 37°C for 4 h; endpoint: mean lifespanupyesA2; stressor: 250 µM juglone; endpoint: survivaldownyesA5; measured via H2DCF-DAupyesA2; SOD activitynonenoA2; catalase activityup16.45yesupn.d.Asthana J, Mishra BN, Pandey R (2016) Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res 50, 861-874. no
5 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°CdownyesAsthana J, Mishra BN, Pandey R (2016) Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res 50, 861-874. no
25 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°CdownyesAsthana J, Mishra BN, Pandey R (2016) Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res 50, 861-874. no
50 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°CdownyesAsthana J, Mishra BN, Pandey R (2016) Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res 50, 861-874. no
25 µMwhole life; start: L1OP50NGM agarFUDRTK22 [mev-1(kn1)]20°Cup40.50yesupn.d.Asthana J, Mishra BN, Pandey R (2016) Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res 50, 861-874. no
25 µMwhole life; start: L1OP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CupyesA1; sod-3 expression measured via fluorescenceAsthana J, Mishra BN, Pandey R (2016) Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res 50, 861-874. no
25 µMwhole life; start: L1OP50NGM agarCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CupyesA1; gst-4 expression measured via fluorescenceAsthana J, Mishra BN, Pandey R (2016) Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res 50, 861-874. no
25 µMwhole life; start: L1OP50NGM agarNL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}20°CdownyesA1; measured via fluorescenceAsthana J, Mishra BN, Pandey R (2016) Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res 50, 861-874. no