| Treatment | Erchen wan (TCM formula) | reproductive function | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | number of offspring | heat stress resistance | oxidative stress resistance | median lifespan | mean lifespan | ||||||||||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 1.5 g/l | whole life; start: L4 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | n.d. | down | -15.80 | n.d. | down | -9.40 | no | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||||||
| 7.3 g/l | whole life; start: L4 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | n.d. | down | -8.10 | n.d. | down | -4.00 | no | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||||||
| 14.5 g/l | whole life; start: L4 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | n.d. | down | -16.00 | n.d. | down | -15.70 | yes | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||||||
| 1.5 g/l | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | n.d. | up | 14.70 | n.d. | up | 21.80 | yes | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||||||
| 1.5 g/l | whole life; start: L1 | OP50 | NGM agar | FUDR | N2 (wild type) | n.d. | down | yes | up | 162.85 | yes | A1; stressor: 35°C for 22.5 h; endpoint: survival | up | 2.98 | no | L1; stressor: 10 mM paraquat; endpoint: survival after 3.5 days | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||
| 1.5 g/l | whole life; start: L1 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | n.d. | down | no | down | -66.92 | yes | A1; stressor: 35°C for 28 h; endpoint: survival | up | 58.88 | yes | L1; stressor: 10 mM paraquat; endpoint: survival after 3.5 days | Wan F, Zhi D, Liu D, Xian J, Li M, AbuLizi A, Ju W, Li H (2014) Lifespan extension in Caenorhabiditis elegans by several traditional Chinese medicine formulas. Biogerontology 15, 377-387. | |||||||||||||||