Treatment | Folic acid | cognitive function | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | 135398658 | ChEMBL | CHEMBL1622 | chemotaxis | pharyngeal pumping | body length / growth rate | number of offspring | reproductive total span | heat stress resistance | oxidative stress resistance | autofluorescence (age pigment / lipofuscin) | ROS level | activity / quantity / expression of SODs | activity / quantity / expression of GSTs | mean lifespan | maximum lifespan | ||||||||||||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
10 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | yes | A2, A5, and A10 | down | yes | A10; blue fluorescence | up | 17.14 | yes | up | 27.44 | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | yes | A2, A5, and A10 | up | yes | A5 and A10; unchanged at a2; endpoint: length and width | up | 26.57 | yes | up | 48.40 | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||
50 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | yes | A2, A5, and A10 | up | 0.24 | no | down | -9.68 | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | |||||||||||||||||||||||||||||||||||||||||||||||
100 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | none | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
250 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
500 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 mM | whole life; start: egg stage | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50, heat-inactivated | NGM agar | FUDR | N2 (wild type) | 20°C | up | 14.97 | yes | up | 14.16 | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | N2 (wild type) | 20°C | up | yes | A2; attractant: 1 M sodium acetate | down | -16.95 | n.d. | up | n.d. | none | no | A2; stressor: 35°C for 3 h; endpoint: survival | up | yes | A2; stressor: 250 µM juglone for 6 h; endpoint: survival | down | -46.80 | yes | A2; exposed to 37°C during measurement; measured via H2DCF-DA | up-regulation of pha-4, sir-2.1, daf-16, skn-1, sod-3, and gst-4 | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | 20°C | up | 13.29 | yes | up | 16.37 | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | DA1116 [eat-2(ad1116)] | 20°C | up | 0.83 | no | none | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | |||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | GR1307 [daf-16(mgDf50)] | 20°C | up | 1.03 | no | up | 11.90 | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | VC199 [sir-2.1(ok434)] | 20°C | down | -0.32 | no | down | -4.23 | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | FUDR | EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]] | 20°C | up | 3.85 | no | up | 3.49 | n.d. | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | up | yes | A2; gst-4 expression | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | up | yes | A2; sod-3 expression | Rathor L, Akhoon BA, Pandey S, Srivastava S, Pandey R (2015) Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) 37, 113. | no |