Compound ID 245 (prev - next)

Name: Mulberry leaf polyphenols (edit)

19 entries:

Treatment	Mulberry leaf polyphenols						reproductive function								physiological function				healthspan biomarkers				lifespan				Transcriptome	Target	Reference
CID (PubChem)		ChEMBL					number of offspring				reproductive total span				oxidative stress resistance				triglyceride / fat / lipid content				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
25 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C									up		yes	A 8, A10, A12, A14, and A16; stressor: 5 mM paraquat; endpoint: survival					up	25.87	yes		up-regulation of sod-3, lipl-4, fard-1, unc-51, fat-6, and gst-4	germline signaling pathway, DAF-12, DAF-16, PHA-4, NHR-80, fat-6, lipl-4, sod-3, unc-51, and fard-1	Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
25 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	25°C																	up	22.46	yes				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
25 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	CF1038 [daf-16(mu86)]	20°C																	up	4.67	no				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
25 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	AA86 [daf-12(rh61rh411)]	20°C																	up	3.80	no				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
25 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	BX165 [nhr-80(tm1011)]	20°C																	up	2.34	no				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
25 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	SM190 [smg-1(cc546); pha-4(zu225)]	20°C																	up	3.82	no				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
25 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	20°C																	up	8.73	yes				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
25 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	CF1903 [glp-1(e2144)]	25°C													up	2.81	no		up	0.60	no		up-regulation of gst-4; unchanged expression of sod-3, lipl-4, fard-1, unc-51, and fat-6		Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
25 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]	20°C																	up	10.99	yes				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
25 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	TK22 [mev-1(kn1)]	20°C																	up	22.58	yes				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
1 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																	down	-3.00	no				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
5 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																	up	13.00	yes				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
125 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																	down	-2.00	no				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
312.5 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																	down	-14.00	yes				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
625 mg/l	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																	down	-18.00	yes				Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.
25 mg/l	whole life; start: A1	OP50, heat-inactivated	NGM agar		N2 (wild type)	20°C	down	-27.15	yes		down	-28.17	yes		up	211.11	yes	A6; stressor: 1.5 mM H2O2 for 5 h; endpoint: survival; enhanced resistance also by the use of 0.5 mM or 1 mM H2O2	up	37.00	yes	unclear, since decreased staining is seen in the picture and is also described in text, but increased staining is shown in the graph and the supplementary table							Zheng S, Liao S, Zou Y, Qu Z, Shen W, Shi Y (2014) Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans. Age (Dordr) 36, 9719.