Compound ID 280   (prev - next)

Name: Polydatin (5281718) (edit)

13 entries:
TreatmentPolydatinphysical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)5281718ChEMBLlocomotion in liquid mediaoxidative stress resistanceactivity / quantity / expression of SODsactivity / quantity / expression of GSTstranslocation of DAF-16 to nucleusmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
0.01 mM24 h; start: L1OP50liquid K-mediumN2 (wild type)20°Cup17.05yesyoung adults; stressor: 500 µMCu2+ for 24 h; endpoint: mean lifespanup11.19yesup-regulation of daf-16, daf-2, and sir-2.1; down-regulation of skn-1daf-2, daf-16, sod-3Wen H, Gao X, Qin J (2014) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6, 35-43.
0.1 mM24 h; start: L1OP50liquid K-mediumN2 (wild type)20°Cup26.61noyoung adults; stressor: 500 µMCu2+ for 24 h; endpoint: mean lifespanup17.48yesup-regulation of daf-16; down-regulation of daf-2, sir-2.1, and skn-1daf-2, daf-16, sod-3Wen H, Gao X, Qin J (2014) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6, 35-43.
1 mM24 h; start: L1OP50liquid K-mediumN2 (wild type)20°CupyesA1, A3, and A5; significant change in A3 and A5 after pre-exposure to Cu2+ and in A3 without pre-exposureup61.50yesyoung adults; stressor: 500 µMCu2+ for 24 h; endpoint: mean lifespanup30.07noup-regulation of daf-16; down-regulation of daf-2daf-2, daf-16, sod-3Wen H, Gao X, Qin J (2014) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6, 35-43.
1 mM24 h; start: L1OP50liquid K-mediumCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CdownyesA1, A3, and A5; pre-exposed to Cu2+; similar change without Cu2+ in A3 and A5, but unchanged in A1; measured by fluorescenceWen H, Gao X, Qin J (2014) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6, 35-43.
0.01 mM24 h; start: L1OP50liquid K-mediumTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CupyesA3; no significant changes in A1 and A5Wen H, Gao X, Qin J (2014) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6, 35-43.
0.1 mM24 h; start: L1OP50liquid K-mediumTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CupyesA3; no significant changes in A1 and A5Wen H, Gao X, Qin J (2014) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6, 35-43.
1 mM24 h; start: L1OP50liquid K-mediumTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CupyesA1, A3, and A5Wen H, Gao X, Qin J (2014) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6, 35-43.
0.01 mM24 h; start: L1OP50liquid K-mediumCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CupnoA1, A3, and A5; measured by fluorescenceWen H, Gao X, Qin J (2014) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6, 35-43.
0.1 mM24 h; start: L1OP50liquid K-mediumCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CupnoA1, A3, and A5; measured by fluorescenceWen H, Gao X, Qin J (2014) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6, 35-43.
1 mM24 h; start: L1OP50liquid K-mediumCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CupyesA1, A3, and A5; measured by fluorescenceWen H, Gao X, Qin J (2014) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6, 35-43.