Compound ID 281 (prev - next)

Name: Polygonum multiflorum extract (135281013) (edit)

34 entries:

Treatment	Polygonum multiflorum extract						physical function								reproductive function				physiological function								healthspan biomarkers																lifespan								Reference	blinded
CID (PubChem)	135281013	ChEMBL					pharyngeal pumping				body length / growth rate				number of offspring				heat stress resistance				oxidative stress resistance				autofluorescence (age pigment / lipofuscin)				ROS level				translocation of SKN-1 to nucleus				translocation of DAF-16 to nucleus				median lifespan				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
1 µg/ml	start: L4; stop: A3	OP50	liquid NGM	FUdR	N2 (wild type)	20°C																	up	0,9	no	A3; stressor: 50 mM paraquat; endpoint: mean survival																									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
5 µg/ml	start: L4; stop: A3	OP50	liquid NGM	FUdR	N2 (wild type)	20°C																	down	-2,2	no	A3; stressor: 50 mM paraquat; endpoint: mean survival																									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
10 µg/ml	start: L4; stop: A3	OP50	liquid NGM	FUdR	N2 (wild type)	20°C																	up	0,6	no	A3; stressor: 50 mM paraquat; endpoint: mean survival																									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
50 µg/ml	start: L4; stop: A3	OP50	liquid NGM	FUdR	N2 (wild type)	20°C																	none		no	A3; stressor: 50 mM paraquat; endpoint: mean survival																									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
100 µg/ml	start: L4; stop: A3	OP50	liquid NGM	FUdR	N2 (wild type)	20°C																	up	1,8	no	A3; stressor: 50 mM paraquat; endpoint: mean survival																									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
500 µg/ml	start: L4; stop: A3	OP50	liquid NGM	FUdR	N2 (wild type)	20°C																	up	12,6	yes	A3; stressor: 50 mM paraquat; endpoint: mean survival																									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	start: L4; stop: A3	OP50	liquid NGM	FUdR	N2 (wild type)	20°C													none		no	A3; stressor: 37°C; endpoint: survival	up	8,8	yes	A3; stressor: 50 mM paraquat; endpoint: mean survival																									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
100 µg/ml	start: L4; stop: A3	OP50	liquid NGM		N2 (wild type)	20°C																					down		no	A3; blue fluorescence																					Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
500 µg/ml	start: L4; stop: A3	OP50	liquid NGM		N2 (wild type)	20°C																					down		no	A3; blue fluorescence																					Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	start: L4; stop: A3	OP50	liquid NGM		N2 (wild type)	20°C																					down		no	A3; blue fluorescence																					Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	start: L4; stop: A2	OP50	liquid NGM		N2 (wild type)	20°C																									down	-71,6	yes	A2; exposure to 37°C; measured via DCF-Da																	Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
10 µg/ml	whole life; start: L4	OP50	liquid NGM	FUdR	N2 (wild type)	25°C																																					none		n.d.		up	1,5	no		Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
100 µg/ml	whole life; start: L4	OP50	liquid NGM	FUdR	N2 (wild type)	25°C																																					none		n.d.		up	4,8	no		Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	whole life; start: L4	OP50	liquid NGM	FUdR	N2 (wild type)	25°C																																					up	22,2	n.d.		up	18,6	yes		Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	start: L4; stop: A3	OP50	liquid NGM	FUdR	CF1038 [daf-16(mu86)]	20°C																	up	25,8	yes	A3; stressor: 50 mM paraquat; endpoint: mean survival																									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	start: L4; stop: A2	OP50	liquid NGM		CF1038 [daf-16(mu86)]	20°C																									down		no	A2; exposure to 37°C; measured via DCF-Da																	Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	whole life; start: L4	OP50	liquid NGM	FUdR	CF1038 [daf-16(mu86)]	25°C																																					none		n.d.		up	3,7	no		Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
100 µg/ml	1 h; start: L4/A1	OP50	liquid NGM		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																																	none		no	A1									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
500 µg/ml	1 h; start: L4/A1	OP50	liquid NGM		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																																	up		no	A1									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	1 h; start: L4/A1	OP50	liquid NGM		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																																	up	44,5	yes	A1									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	start: L4; stop: A3	OP50	liquid NGM	FUdR	VC199 [sir-2.1(ok434)]	20°C																	down	-3,5	no	A3; stressor: 50 mM paraquat; endpoint: mean survival																									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	start: L4; stop: A2	OP50	liquid NGM		VC199 [sir-2.1(ok434)]	20°C																									down		yes	A2; exposure to 37°C; measured via DCF-Da																	Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	whole life; start: L4	OP50	liquid NGM	FUdR	VC199 [sir-2.1(ok434)]	25°C																																					none		n.d.		down	-0,8	no	hier	Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
100 µg/ml	1 h; start: L4/A1	OP50	liquid NGM		LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]}	20°C																													down		no	A1													Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
500 µg/ml	1 h; start: L4/A1	OP50	liquid NGM		LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]}	20°C																													down		no	A1													Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	1 h; start: L4/A1	OP50	liquid NGM		LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]}	20°C																													down		no	A1													Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	start: L4; stop: A4	OP50	liquid NGM		N2 (wild type)	20°C	none		no	A4																																									Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
100 µg/ml	start: L4; stop: A3	OP50	liquid NGM		N2 (wild type)	20°C					none		no	A4																																					Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
500 µg/ml	start: L4; stop: A3	OP50	liquid NGM		N2 (wild type)	20°C					none		no	A4																																					Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	start: L4; stop: A3	OP50	liquid NGM		N2 (wild type)	20°C					none		no	A4																																					Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no
1000 µg/ml	whole life; start: L4	OP50	liquid NGM		N2 (wild type)	20°C									down		no																																		Saier, C., Büchter, C., Koch, K., & Wätjen, W. (2018). Polygonum multiflorum extract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7(3), 60.	no